Anafranil and Pamelor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Anafranil (clomipramine hydrochloride) and Pamelor (nortriptyline hydrochloride). Common drug interactions include completed suicide among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Anafranil and Pamelor. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Anafranil?

Anafranil has active ingredients of clomipramine hydrochloride. It is often used in obsessive-compulsive disorder. eHealthMe is studying from 6,304 Anafranil users. Check the latest studies of Anafranil.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.

On Jul, 11, 2026

11 people who take Anafranil and Pamelor together, and have interactions are studied.

Anafranil and Pamelor drug interactions.

What are the common drug interactions of Anafranil and Pamelor, by gender? *:

female:

Completed suicide (act of taking one's own life)
Intervertebral disc protrusion (spinal disc protrusion)
Nausea (feeling of having an urge to vomit)
Pain

male:

Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Abdominal pain
Constipation
Drug ineffective
Ear infection
Heart rate increased
Influenza

What are the common drug interactions of Anafranil and Pamelor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Agitation (state of anxiety or nervous excitement)
Increased appetite
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Asthenia (weakness)
Confusional state
Delirium (wild excitement)
Depressed mood
Dizziness
Eating disorder

30-39:

n/a

40-49:

n/a

50-59:

Completed suicide (act of taking one's own life)

60+:

n/a

What are the existing conditions these people have? *

Stress And Anxiety: 1 person, 9.09%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 9.09%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 1 person, 9.09%
Panic Disorder: 1 person, 9.09%
Pain: 1 person, 9.09%
Neuralgia (pain in one or more nerves): 1 person, 9.09%
Labyrinthitis (inflammation of the labyrinth or inner ear): 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%
Headache (pain in head): 1 person, 9.09%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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