Ancef and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ancef (cefazolin sodium) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include lower respiratory tract infection among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Ancef and Hydramine. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Ancef?

Ancef has active ingredients of cefazolin sodium. eHealthMe is studying from 3,292 Ancef users. Check the latest studies of Ancef.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 12, 2026

41 people who take Ancef and Hydramine together, and have interactions are studied.

What are the common drug interactions of Ancef and Hydramine, by gender? *:

female:

Lower respiratory tract infection
Drug ineffective
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Drug hypersensitivity
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fall
Hypopnoea (decrease in the breathing rate)

male:

Diarrhoea
Fatigue (feeling of tiredness)
Chronic kidney disease
Confusional state
Cough
Headache (pain in head)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Ancef and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Wound secretion

20-29:

Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Adenoma benign (non-cancerous tumour -secreting)
Adnexa uteri cyst (ovarian cysts)
Allergic sinusitis
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Aortic valve sclerosis (narrowing of the aortic valve)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

30-39:

Anaemia (lack of blood)
Bone pain
Discomfort
Injection site inflammation
Kidney transplant rejection
Lymph node pain
Lymphadenopathy (disease or enlargement of lymph nodes)
Pain
Pruritus (severe itching of the skin)
Pyrexia (fever)

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Hypopnoea (decrease in the breathing rate)
Injection site extravasation (flow of (blood or lymph) from injection site)
Joint swelling
Lower respiratory tract infection
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pneumonia
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Skin ulcer
Traumatic haematoma (a blood clot in body due to trauma)
Weight decreased

60+:

Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)
Pain
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Agitation (state of anxiety or nervous excitement)
Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Bacterial infection
Blood creatinine increased
Blood iron decreased

What are the existing conditions these people have? *

Pain: 7 people, 17.07%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 12.20%
Itching: 4 people, 9.76%
Immunodeficiency Common Variable: 4 people, 9.76%
High Blood Pressure: 4 people, 9.76%
Nausea (feeling of having an urge to vomit): 3 people, 7.32%
Multiple Myeloma (cancer of the plasma cells): 3 people, 7.32%
Hypersensitivity: 3 people, 7.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.32%
Anaesthesia: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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