Anusol hc and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Anusol hc (hydrocortisone) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include abdominal pain upper among females and loss of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Anusol hc and Flexeril. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Anusol hc?

Anusol hc has active ingredients of hydrocortisone. It is often used in hemorrhoids. eHealthMe is studying from 679 Anusol hc users. Check the latest studies of Anusol hc.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 11, 2026

26 people who take Anusol hc and Flexeril together, and have interactions are studied.

Anusol hc and Flexeril drug interactions.

What are the common drug interactions of Anusol Hc and Flexeril, by gender? *:

female:

Abdominal pain upper
Anaemia (lack of blood)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Blood creatine increased
Chest discomfort
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Contusion (a type of hematoma of tissue in which capillaries)
Dehydration (dryness resulting from the removal of water)
Delirium (wild excitement)

male:

Loss of consciousness
Pruritus (severe itching of the skin)
Fatigue (feeling of tiredness)
Abdominal discomfort
Abdominal pain
Abscess limb (limb infection)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Arrhythmia (irregular heartbeat)

What are the common drug interactions of Anusol Hc and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)

20-29:

n/a

30-39:

Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Weight increased
Abdominal pain
Aggression
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Constipation
Crying
Depressed mood

40-49:

Arthralgia (joint pain)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Erythema (redness of the skin)
Hypersensitivity
Pruritus (severe itching of the skin)
Rash
Throat irritation

50-59:

Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Thyroglossal cyst (cyst in the neck)

60+:

Abdominal pain
Abdominal discomfort
Blood creatine increased
Blood pressure decreased
Cellulitis (infection under the skin)
Chest discomfort
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Pain: 6 people, 23.08%
Depression: 4 people, 15.38%
Back Pain: 4 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.54%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 11.54%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 7.69%
Procedural Pain: 2 people, 7.69%
Nausea (feeling of having an urge to vomit): 2 people, 7.69%
Joint Pain: 2 people, 7.69%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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