Anzemet and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Anzemet (dolasetron mesylate) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include pleural effusion among females.

The phase IV clinical study analyzes what interactions people have when they take Anzemet and Flexeril. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Anzemet?

Anzemet has active ingredients of dolasetron mesylate. eHealthMe is studying from 2,603 Anzemet users. Check the latest studies of Anzemet.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Aug, 05, 2026

34 people who take Anzemet and Flexeril together, and have interactions are studied.

What are the common drug interactions of Anzemet and Flexeril, by gender? *:

female:

Pleural effusion (water on the lungs)
Diarrhoea
Osteomyelitis (infection of bone)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Gingival infection (gum infection)
Atelectasis (partial or complete collapse of the lung)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Osteonecrosis of jaw (death of bone of jaw)
Pyrexia (fever)

male:

n/a

What are the common drug interactions of Anzemet and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Depression
Loss of consciousness
Respiratory failure (inadequate gas exchange by the respiratory system)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Aggression
Agitation (state of anxiety or nervous excitement)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Borderline personality disorder

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Artificial menopause
Atelectasis (partial or complete collapse of the lung)
Bone pain
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Depression

50-59:

Cellulitis (infection under the skin)
Colitis ulcerative (inflammation of colon with ulcer)
Cor pulmonale chronic (long lasting enlargement of the right ventricle of the heart)
Dental caries
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Enteritis (inflammation of the small intestine)
Enterococcal infection
Escherichia infection (bacterial infection by escherichia coli)
Essential thrombocythaemia (chronic blood cancer)

60+:

Pleural effusion (water on the lungs)
Abdominal pain
Cardiac failure chronic
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dental caries
Dental discomfort
Diarrhoea
Diverticulum intestinal haemorrhagic (a pouch that is attached to the first part of the small intestine with bleeding)

What are the existing conditions these people have? *

Stress And Anxiety: 18 people, 52.94%
Pain In Jaw: 12 people, 35.29%
Multiple Myeloma (cancer of the plasma cells): 12 people, 35.29%
Thrombocytopenia (decrease of platelets in blood): 8 people, 23.53%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 8 people, 23.53%
Osteoporosis (bones weak and more likely to break): 8 people, 23.53%
Metastases To Bone (cancer spreads to bone): 6 people, 17.65%
Breast Cancer: 6 people, 17.65%
Back Pain: 6 people, 17.65%

* Approximation only. Some reports may have incomplete information.

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