Apidra and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apidra (insulin glulisine recombinant) and Ultram (tramadol hydrochloride). Common drug interactions include thyroid mass among females and foot deformity among males.

The phase IV clinical study analyzes what interactions people have when they take Apidra and Ultram. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Apidra?

Apidra has active ingredients of insulin glulisine recombinant. It is often used in diabetes. eHealthMe is studying from 10,548 Apidra users. Check the latest studies of Apidra.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

22 people who take Apidra and Ultram together, and have interactions are studied.

What are the common drug interactions of Apidra and Ultram, by gender? *:

female:

Thyroid mass
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Pancreatitis (inflammation of pancreas)
Pulmonary embolism (blockage of the main artery of the lung)
Arthropathy
Eye disorder
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Papillary thyroid cancer
Coronary artery stenosis (narrowing of coronary artery)

male:

Foot deformity (functional disability of foot)
Headache (pain in head)
Cardiac disorder
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Cystitis interstitial (unknown cause characterized by bladder pain)
Death

What are the common drug interactions of Apidra and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pulmonary embolism (blockage of the main artery of the lung)
Cough

50-59:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Papillary thyroid cancer
Anal abscess
Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Genital abscess (build up of pus in genital)
Headache (pain in head)

60+:

Arthropathy
Eye disorder
Behcet's syndrome (involves inflammation of the blood vessels)
Blood glucose decreased
Blood glucose increased
Bradyarrhythmia (heart slowness)
Cardiac disorder
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain

What are the existing conditions these people have? *

Type 2 Diabetes: 7 people, 31.82%
Muscle Spasms (muscle contraction): 4 people, 18.18%
High Blood Pressure: 4 people, 18.18%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 13.64%
Cough: 3 people, 13.64%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 13.64%
Migraine (headache): 3 people, 13.64%
High Blood Cholesterol: 2 people, 9.09%
Depression: 2 people, 9.09%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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