Apple cider vinegar and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apple cider vinegar (apple cider vinegar) and Synthroid (levothyroxine sodium). Common drug interactions include gallbladder disorder among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Apple cider vinegar and Synthroid. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Apple cider vinegar?

Apple cider vinegar has active ingredients of apple cider vinegar. It is often used in weight loss. eHealthMe is studying from 1,380 Apple cider vinegar users. Check the latest studies of Apple cider vinegar.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

On Jul, 12, 2026

64 people who take Apple cider vinegar and Synthroid together, and have interactions are studied.

Apple cider vinegar and Synthroid drug interactions.

What are the common drug interactions of Apple Cider Vinegar and Synthroid, by gender? *:

female:

Gallbladder disorder
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Infusion site reaction
Infusion site urticaria (rash of round, red welts on the skin at infusion site)
Limb discomfort (discomfort in leg)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Neck pain
Oedema peripheral (superficial swelling)
Pain in extremity

male:

Neuropathy peripheral (surface nerve damage)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diastolic dysfunction
Gait disturbance
Head injury
Headache (pain in head)
Hydrocephalus (water on the brain)
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Apple Cider Vinegar and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injection site bruising

40-49:

Blood urine present
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Nausea (feeling of having an urge to vomit)
Renal disorder (kidney disease)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Weight decreased
Arthropathy
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)

50-59:

Diastolic dysfunction
Dry skin
Gait disturbance
Head injury
Headache (pain in head)
Hydrocephalus (water on the brain)
Hyperhidrosis (abnormally increased sweating)
Impaired driving ability
Intervertebral disc degeneration (spinal disc degeneration)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)

60+:

Weight decreased
Weight increased
Iron deficiency anaemia
Pain
Fatigue (feeling of tiredness)
Abdominal discomfort
Cataract (clouding of the lens inside the eye)
Drug ineffective
Eye infection
Haemorrhage (bleeding)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 15.62%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 6 people, 9.38%
Immunodeficiency Common Variable: 5 people, 7.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.81%
Asthma: 5 people, 7.81%
Thyroid Diseases: 4 people, 6.25%
High Blood Pressure: 4 people, 6.25%
High Blood Cholesterol: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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