Apresoline and Centrum silver drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apresoline (hydralazine hydrochloride) and Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include failure to thrive among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Apresoline and Centrum silver. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Apresoline?

Apresoline has active ingredients of hydralazine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,475 Apresoline users. Check the latest studies of Apresoline.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

38 people who take Apresoline and Centrum silver together, and have interactions are studied.

Apresoline and Centrum silver drug interactions.

What are the common drug interactions of Apresoline and Centrum Silver, by gender? *:

female:

Failure to thrive (inadequate weight gain and physical growth in children)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperproteinaemia (a metabolic disorder characterized by enhanced plasma proline concentrations and urinary excretion)
Plasma cell myeloma (cancer that begins in plasma cells)
Sepsis (a severe blood infection that can lead to organ failure and death)
Chronic kidney disease
Anaemia (lack of blood)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)
Antinuclear antibody positive

male:

Asthenia (weakness)
Sepsis (a severe blood infection that can lead to organ failure and death)
Apnoea (suspension of external breathing)
Arthralgia (joint pain)
Arthropathy
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Bone disorder
Bone pain

What are the common drug interactions of Apresoline and Centrum Silver, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthropathy
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Axonal neuropathy (dysfunction of axon nerves)
Back pain
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bone disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone pain

60+:

Asthenia (weakness)
Sepsis (a severe blood infection that can lead to organ failure and death)
Anxiety
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pain
Apnoea (suspension of external breathing)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Atelectasis (partial or complete collapse of the lung)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 36.84%
Nausea (feeling of having an urge to vomit): 9 people, 23.68%
High Blood Cholesterol: 9 people, 23.68%
Sleep Disorder: 8 people, 21.05%
Pain: 8 people, 21.05%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 18.42%
Nervousness: 6 people, 15.79%
Constipation: 5 people, 13.16%
Muscle Spasms (muscle contraction): 4 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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