Apriso and Pramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Apriso (mesalamine) and Pramine (imipramine hydrochloride). Common drug interactions include menopause among females and ileus among males.

The phase IV clinical study analyzes what interactions people have when they take Apriso and Pramine. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Apriso?

Apriso has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 3,439 Apriso users. Check the latest studies of Apriso.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

18 people who take Apriso and Pramine together, and have interactions are studied.

What are the common drug interactions of Apriso and Pramine, by gender? *:

female:

Menopause (end of monthly cycles in women)
Renal failure (kidney dysfunction)
Inflammation
Drug ineffective
Hip arthroplasty
Restless legs syndrome (a powerful urge to move your legs)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Incontinence (lack of moderation or self-control)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

male:

Ileus (a painful obstruction of the ileum or other part of the intestine)
Small intestinal obstruction (blockage in small intestine)
Splenic infarction (tissue damage of spleen)
Injection site pain

What are the common drug interactions of Apriso and Pramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

Drug ineffective
Ileus (a painful obstruction of the ileum or other part of the intestine)
Restless legs syndrome (a powerful urge to move your legs)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Small intestinal obstruction (blockage in small intestine)
Splenic infarction (tissue damage of spleen)
Stress
Injection site pain

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 66.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 66.67%
Pain: 3 people, 16.67%
High Blood Cholesterol: 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 16.67%
Stress And Anxiety: 2 people, 11.11%
Abdominal Pain: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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