Aranesp and Periactin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aranesp (darbepoetin alfa) and Periactin (cyproheptadine hydrochloride). Common drug interactions include anhedonia among females and neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Aranesp and Periactin. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Aranesp?

Aranesp has active ingredients of darbepoetin alfa. It is often used in anemia. eHealthMe is studying from 54,331 Aranesp users. Check the latest studies of Aranesp.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12 people who take Aranesp and Periactin together, and have interactions are studied.

Aranesp and Periactin drug interactions.

What are the common drug interactions of Aranesp and Periactin, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Cholecystitis (infection of gallbladder)
Emotional distress
Gallbladder injury
General physical health deterioration (weak health status)
Injury
Malignant neoplasm progression (cancer tumour came back)
Pain

male:

Neutropenia (an abnormally low number of neutrophils)
Pleural effusion (water on the lungs)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal impairment (severely reduced kidney function)
Tibia fracture (fracture of lower leg bone)
Vitamin b12 decreased
Wheezing (a high-pitched whistling sound made while you breath)
Blood glucose increased
Emotional distress
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)

What are the common drug interactions of Aranesp and Periactin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Cholecystitis (infection of gallbladder)
Emotional distress
Gallbladder injury
General physical health deterioration (weak health status)
Injury
Pain
Renal failure (kidney dysfunction)

40-49:

Anaemia (lack of blood)
Ankle fracture
Chronic kidney disease
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal impairment (severely reduced kidney function)
Tibia fracture (fracture of lower leg bone)
Vitamin b12 decreased
Wheezing (a high-pitched whistling sound made while you breath)
Emotional distress

50-59:

Neutropenia (an abnormally low number of neutrophils)
Hypovolaemia (a decreased volume of circulating blood in the body)
Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces)
Activated partial thromboplastin time prolonged
Bacteria stool identified
Blood alkaline phosphatase increased
Culture stool positive
Hepatic mass
International normalised ratio increased
Metastases to liver (cancer spreads to liver)

60+:

Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 5 people, 41.67%
Hiv Infection: 2 people, 16.67%
Gout (uric acid crystals building up in the body): 2 people, 16.67%
Anaemia (lack of blood): 2 people, 16.67%
Premenstrual Syndrome: 1 person, 8.33%
Metastases To Liver (cancer spreads to liver): 1 person, 8.33%
Diabetes: 1 person, 8.33%
Cytomegalovirus Infection: 1 person, 8.33%
Cough: 1 person, 8.33%
Colon Cancer: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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