Arava and Celestone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Celestone (betamethasone). Common drug interactions include sleep disorder due to a general medical condition among females and aortic atherosclerosis among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Celestone. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Celestone?

Celestone has active ingredients of betamethasone. It is often used in bursitis. eHealthMe is studying from 1,788 Celestone users. Check the latest studies of Celestone.

On Jul, 09, 2026

24 people who take Arava and Celestone together, and have interactions are studied.

What are the common drug interactions of Arava and Celestone, by gender? *:

female:

Sleep disorder due to a general medical condition
Accident
Alanine aminotransferase increased
Angioedema (rapid swelling of the dermis)
Arterial stenosis (abnormal narrowing of the aortic valve in the heart)
Arterial stent insertion
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood lactate dehydrogenase increased

male:

Aortic atherosclerosis (degenerative process of aortic arteries)
Blood lactate dehydrogenase increased
Infection
Infection in an immunocompromised host
Interstitial lung disease
Lung abscess (pus in lungs)
Melanosis (a disorder of pigmentation of the wall of the colon)
Pleural fibrosis (formation of fibrous tissue in lung)
Pneumonia
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)

What are the common drug interactions of Arava and Celestone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood lactate dehydrogenase increased
Gamma-glutamyltransferase increased
Liver disorder (liver diseases)
Purpura (purplish discoloration of the skin)
Rash

30-39:

n/a

40-49:

n/a

50-59:

Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site vesicles (fluid- or air-filled cavity or sac at injection site)
Joint swelling
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Skin infection
Skin lesion
Sleep disorder due to a general medical condition
Swelling

60+:

Drug ineffective
Accident
Gastritis bacterial (inflammation of stomach caused by bacterial infection)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Hypoxia (low oxygen in tissues)
Impaired healing
Infection
Infection in an immunocompromised host

What are the existing conditions these people have? *

Pain: 9 people, 37.50%
Injection Site Vesicles (fluid- or air-filled cavity or sac at injection site): 2 people, 8.33%
Injection Site Pain: 2 people, 8.33%
Asthma: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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