Provera and Invega drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provera (medroxyprogesterone acetate) and Invega (paliperidone). Common drug interactions include galactorrhoea among females.

The phase IV clinical study analyzes what interactions people have when they take Provera and Invega. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Invega?

Invega has active ingredients of paliperidone. It is often used in bipolar disorder. eHealthMe is studying from 32,353 Invega users. Check the latest studies of Invega.

On Jul, 09, 2026

19 people who take Provera and Invega together, and have interactions are studied.

What are the common drug interactions of Provera and Invega, by gender? *:

female:

Galactorrhoea (secretion of breast milk in men)
Weight increased
Gallbladder disorder
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperprolactinaemia (abnormally high levels of prolactin in the blood)
Injury
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Urinary tract infection
Vomiting

male:

n/a

What are the common drug interactions of Provera and Invega, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood prolactin increased
Galactorrhoea (secretion of breast milk in men)
Bruxism (habitual grinding of the teeth, typically during sleep)
Drug ineffective
Hypertension (high blood pressure)
Injection site swelling
Joint swelling
Rash
Rash papular (redness with papule)
Rash vesicular (rash with a small bubble)

20-29:

Abdominal pain upper
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Gallbladder disorder
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Injury
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Vomiting
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)

30-39:

Weight increased
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Galactorrhoea (secretion of breast milk in men)
Urinary tract infection

40-49:

Bone pain
Injection site pain
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myalgia (muscle pain)
Pain

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 15.79%
Affective Disorder (mental disorder): 3 people, 15.79%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 10.53%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 10.53%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 1 person, 5.26%
Mood Swings (an extreme or rapid change in mood): 1 person, 5.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.26%
Hormone Level Abnormal: 1 person, 5.26%
High Blood Pressure: 1 person, 5.26%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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