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Metformin and High density lipoprotein increased - a phase IV clinical study of FDA data

Summary:

High density lipoprotein increased is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Lipitor, and have High blood cholesterol.

The phase IV clinical study analyzes which people have High density lipoprotein increased when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is High density lipoprotein increased?

High density lipoprotein increased is found to be associated with 195 drugs and 354 conditions by eHealthMe. Check the latest studies of High density lipoprotein increased.

On Jul, 09, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 47 people (0.01%) have High density lipoprotein increased.

Could Metformin cause High density lipoprotein increased?

Among these 47 people:

How long have people been on Metformin when they have High density lipoprotein increased? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have High density lipoprotein increased when taking Metformin? *

  • female: 60 %
  • male: 40 %

What is the age of people who have High density lipoprotein increased when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 10.53 %
  • 40-49: 23.68 %
  • 50-59: 39.47 %
  • 60+: 26.32 %

What are other drugs people take besides Metformin? *

  1. Lipitor: 11 people, 23.40%
  2. Gabapentin: 10 people, 21.28%
  3. Lisinopril: 8 people, 17.02%
  4. Synthroid: 8 people, 17.02%
  5. Lyrica: 7 people, 14.89%
  6. Glipizide: 7 people, 14.89%
  7. Abilify: 6 people, 12.77%
  8. Levothyroxine Sodium: 6 people, 12.77%
  9. Prevacid: 6 people, 12.77%
  10. Lorazepam: 6 people, 12.77%

What are other side effects people have besides High density lipoprotein increased? *

  1. Glycosylated Haemoglobin Increased: 16 people, 34.04%
  2. High Blood Cholesterol: 15 people, 31.91%
  3. Low Density Lipoprotein Increased (cholesterol increased in blood): 15 people, 31.91%
  4. Blood Glucose Increased: 13 people, 27.66%
  5. Aspartate Aminotransferase Increased: 12 people, 25.53%
  6. Pain In Extremity: 12 people, 25.53%
  7. Abdominal Pain: 11 people, 23.40%
  8. Pain: 10 people, 21.28%
  9. Joint Pain: 10 people, 21.28%
  10. Haemoglobin Decreased: 10 people, 21.28%

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 7 people, 14.89%
  2. Pain: 5 people, 10.64%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 8.51%
  4. Depression: 4 people, 8.51%
  5. Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 8.51%
  6. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 6.38%
  7. Post-Traumatic Stress Disorder: 3 people, 6.38%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 6.38%
  9. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.38%
  10. High Blood Pressure: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have High density lipoprotein increased?

- Check whether High density lipoprotein increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

High density lipoprotein increased treatments and more:

How severe was High density lipoprotein increased and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with High density lipoprotein increased:

Browse all the conditions that are associated with High density lipoprotein increased:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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