Vyvanse and Movantik drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vyvanse (lisdexamfetamine dimesylate) and Movantik (naloxegol oxalate). Common drug interactions include dysphagia among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Vyvanse and Movantik. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

What is Movantik?

Movantik has active ingredients of naloxegol oxalate. It is often used in constipation. eHealthMe is studying from 3,523 Movantik users. Check the latest studies of Movantik.



On Jul, 09, 2026

28 people who take Vyvanse and Movantik together, and have interactions are studied.

Vyvanse and Movantik drug interactions.

What are the common drug interactions of Vyvanse and Movantik, by gender? *:

female:

  1. Dysphagia (a condition in which swallowing is difficult or painful)
  2. Staphylococcal infection (an infection with staphylococcus bacteria)
  3. Fall
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness)
  5. Dyskinesia (abnormality or impairment of voluntary movement)
  6. Memory impairment
  7. Muscle tightness
  8. Abdominal pain upper
  9. Anger
  10. Influenza

male:

  1. Hospitalisation
  2. Hepatic enzyme increased
  3. Tinnitus (a ringing in the ears)
  4. Hypertension (high blood pressure)
  5. Nasopharyngitis (inflammation of the nasopharynx)
  6. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  7. Agitation (state of anxiety or nervous excitement)
  8. Craniocerebral injury (injury to cranium and brain)
  9. Migraine (headache)
  10. Overdose

What are the common drug interactions of Vyvanse and Movantik, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Abdominal pain upper
  2. Anger
  3. Influenza
  4. Hospitalisation
  5. Migraine (headache)
  6. Agitation (state of anxiety or nervous excitement)
  7. Craniocerebral injury (injury to cranium and brain)
  8. Hepatic enzyme increased
  9. Overdose
  10. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

  1. Abdominal pain
  2. Adverse event
  3. Blindness unilateral
  4. Diarrhoea
  5. Foot fracture
  6. Furuncle (infection of the hair follicle)
  7. Hepatic vein thrombosis (obstruction in the veins of the liver caused by a blood clot)
  8. Hospitalisation
  9. Hunger
  10. Limb injury

50-59:

n/a

60+:

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness)
  2. Dyskinesia (abnormality or impairment of voluntary movement)
  3. Memory impairment
  4. Muscle tightness
  5. Dysphagia (a condition in which swallowing is difficult or painful)
  6. Spinal osteoarthritis (joint cartilage loss in spine)
  7. Cardiac failure congestive
  8. General physical health deterioration (weak health status)
  9. Quality of life decreased
  10. Therapeutic response unexpected

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 24 people, 85.71%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 24 people, 85.71%
  3. Drowsiness: 7 people, 25.00%
  4. Depression: 5 people, 17.86%
  5. Neuropathy Peripheral (surface nerve damage): 4 people, 14.29%
  6. Intervertebral Disc Degeneration (spinal disc degeneration): 4 people, 14.29%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 14.29%
  8. Pain: 3 people, 10.71%
  9. Stress And Anxiety: 2 people, 7.14%
  10. Migraine (headache): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vyvanse and Movantik:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vyvanse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Movantik:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vyvanse and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Movantik and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on lisdexamfetamine dimesylate and naloxegol oxalate (the active ingredients of Vyvanse and Movantik, respectively), and Vyvanse and Movantik (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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