Arava and Lialda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Lialda (mesalamine). Common drug interactions include anaphylactic reaction among females.

The phase IV clinical study analyzes what interactions people have when they take Arava and Lialda. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Lialda?

Lialda has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 10,199 Lialda users. Check the latest studies of Lialda.

On Jul, 14, 2026

45 people who take Arava and Lialda together, and have interactions are studied.

What are the common drug interactions of Arava and Lialda, by gender? *:

female:

Anaphylactic reaction (serious allergic reaction)
Headache (pain in head)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chills (felling of cold)
Constipation
Diarrhoea
Dry skin
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphoria (generalized dissatisfaction with life)
Ear pain

male:

n/a

What are the common drug interactions of Arava and Lialda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abnormal loss of weight
Blood pressure decreased
Device failure
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Headache (pain in head)
Muscle spasms (muscle contraction)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Neuropathy peripheral (surface nerve damage)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

Joint swelling
Loss of consciousness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Neck pain
Oedema (fluid collection in tissue)
Oral pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain

60+:

Anaphylactic reaction (serious allergic reaction)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphoria (generalized dissatisfaction with life)
Ear pain
Fatigue (feeling of tiredness)
Gait disturbance

What are the existing conditions these people have? *

Dizziness: 33 people, 73.33%
Pain: 14 people, 31.11%

* Approximation only. Some reports may have incomplete information.

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