Arava and Ruxience drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Ruxience (rituximab-pvvr). Common drug interactions include fracture among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Ruxience. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Ruxience?

Ruxience has active ingredients of rituximab-pvvr. eHealthMe is studying from 4,260 Ruxience users. Check the latest studies of Ruxience.

On Jul, 19, 2026

76 people who take Arava and Ruxience together, and have interactions are studied.

What are the common drug interactions of Arava and Ruxience, by gender? *:

female:

Fracture
Hip fracture
Multiple fractures
Anaemia (lack of blood)
Rash
Gait disturbance
Pericarditis (inflammation of the pericardium)
Vasculitis (inflammation of a blood vessel or blood vessels)
Arthralgia (joint pain)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

Fatigue (feeling of tiredness)
Nasopharyngitis (inflammation of the nasopharynx)
Disease recurrence
Dyspnoea (difficult or laboured respiration)
Interstitial lung disease
Joint swelling
Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)
Localised infection (infection at the single location)
Idiopathic pulmonary fibrosis (chronic lung disease)
Balance disorder

What are the common drug interactions of Arava and Ruxience, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fatigue (feeling of tiredness)
Throat tightness
Anxiety
Back pain
Cough
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Headache (pain in head)
Influenza
Joint stiffness

40-49:

Headache (pain in head)
Eye pruritus (eye itching)
Cough
Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Cardiovascular insufficiency (inadequate functioning of heart)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Disease recurrence
Fatigue (feeling of tiredness)
Influenza

50-59:

Red blood cell sedimentation rate increased
Anal fissure
Blood pressure diastolic increased
Blood pressure increased
Blood pressure systolic increased
C-reactive protein increased
Infusion related reaction
Kidney infection
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)

60+:

Cataract (clouding of the lens inside the eye)
Impaired driving ability
Hip fracture
Multiple fractures
Anaemia (lack of blood)
Idiopathic pulmonary fibrosis (chronic lung disease)
Erythema (redness of the skin)
Drug ineffective
Cardiac failure congestive
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Pneumonia: 4 people, 5.26%
Indigestion: 4 people, 5.26%
Diarrhea: 4 people, 5.26%
Corneal Deposits: 4 people, 5.26%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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