Arava and Trulicity drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arava (leflunomide) and Trulicity (dulaglutide). Common drug interactions include nephrolithiasis among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Arava and Trulicity. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

On Jul, 27, 2026

38 people who take Arava and Trulicity together, and have interactions are studied.

What are the common drug interactions of Arava and Trulicity, by gender? *:

female:

Nephrolithiasis (calculi in the kidneys)
Urinary tract infection
Pyrexia (fever)
Blood glucose increased
Body height decreased
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain upper
Ageusia (loss of taste functions of the tongue)
Allergic sinusitis

male:

Arthralgia (joint pain)
Blood pressure fluctuation
Weight increased
Blood pressure diastolic increased
Tooth fracture
Tooth disorder (tooth disease)
Poor venous access
Adverse drug reaction
Cardiovascular disorder (heart diseases)
Colitis (inflammation of colon)

What are the common drug interactions of Arava and Trulicity, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal distension
Abnormal loss of weight
Anaemia (lack of blood)
Angioedema (rapid swelling of the dermis)
Asthenia (weakness)
Blood pressure increased
Constipation
Cushing's syndrome (obesity, a rounded face, increased fat)
Dehydration (dryness resulting from the removal of water)
Depressed mood

60+:

Arthralgia (joint pain)
Blood pressure fluctuation
Weight increased
Blood pressure diastolic increased
Tooth fracture
Tooth disorder (tooth disease)
Poor venous access
Joint swelling
Colitis (inflammation of colon)
Drug hypersensitivity

What are the existing conditions these people have? *

Diabetes: 18 people, 47.37%
Immunodeficiency Common Variable: 7 people, 18.42%
Primary Immunodeficiency Syndrome: 6 people, 15.79%
Blood Glucose Abnormal: 4 people, 10.53%
Pneumonia: 3 people, 7.89%
Joint Pain: 3 people, 7.89%
High Blood Cholesterol: 3 people, 7.89%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 7.89%
Blood Iron Decreased: 3 people, 7.89%
Blood Glucose Increased: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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