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Arcalyst and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arcalyst (rilonacept) and Profen (ibuprofen). Common drug interactions include chest pain among females.

The phase IV clinical study analyzes what interactions people have when they take Arcalyst and Profen. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Arcalyst?

Arcalyst has active ingredients of rilonacept. eHealthMe is studying from 337 Arcalyst users. Check the latest studies of Arcalyst.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 19, 2026

11 people who take Arcalyst and Profen together, and have interactions are studied.

Arcalyst and Profen drug interactions.

What are the common drug interactions of Arcalyst and Profen, by gender? *:

female:

  1. Chest pain
  2. Chest discomfort
  3. Exophthalmos (bulging or protruding eyeball)
  4. Eye inflammation
  5. Headache (pain in head)
  6. Heart rate irregular
  7. Hypoaesthesia (reduced sense of touch or sensation)
  8. Injection site mass
  9. Injection site pain
  10. Injection site swelling

male:

n/a

What are the common drug interactions of Arcalyst and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Chest pain
  2. Dyspnoea (difficult or laboured respiration)

40-49:

  1. Injection site rash
  2. Chest pain
  3. Dyspnoea (difficult or laboured respiration)
  4. Exophthalmos (bulging or protruding eyeball)
  5. Eye inflammation
  6. Headache (pain in head)
  7. Heart rate irregular
  8. Hypoaesthesia (reduced sense of touch or sensation)
  9. Injection site erythema (redness at injection site)
  10. Injection site mass

50-59:

  1. Chest discomfort
  2. Chest pain
  3. Injection site erythema (redness at injection site)
  4. Leukopenia (less number of white blood cells in blood)
  5. Pyrexia (fever)
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Swelling face
  8. White blood cell count increased

60+:

n/a

What are the existing conditions these people have? *

  1. Pericarditis (inflammation of the pericardium): 7 people, 63.64%
  2. Swelling Face: 1 person, 9.09%
  3. Itching: 1 person, 9.09%
  4. Hypersensitivity: 1 person, 9.09%
  5. Fungal Infection: 1 person, 9.09%
  6. Eye Inflammation: 1 person, 9.09%
  7. Chest Pain: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Arcalyst and Profen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Arcalyst and Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Arcalyst:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Arcalyst and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Profen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on rilonacept and ibuprofen (the active ingredients of Arcalyst and Profen, respectively), and Arcalyst and Profen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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