Aredia and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aredia (pamidronate disodium) and Vytorin (ezetimibe; simvastatin). Common drug interactions include osteonecrosis of jaw among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Aredia and Vytorin. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Aredia?

Aredia has active ingredients of pamidronate disodium. It is often used in breast cancer. eHealthMe is studying from 15,364 Aredia users. Check the latest studies of Aredia.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

On Jul, 08, 2026

76 people who take Aredia and Vytorin together, and have interactions are studied.

What are the common drug interactions of Aredia and Vytorin, by gender? *:

female:

Osteonecrosis of jaw (death of bone of jaw)
Injury
Back pain
Anxiety
Fall
Spinal osteoarthritis (joint cartilage loss in spine)
Osteopenia (a condition where bone mineral density is lower than normal)
Atelectasis (partial or complete collapse of the lung)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyperlipidaemia (presence of excess lipids in the blood)

male:

Pain
Osteonecrosis of jaw (death of bone of jaw)
Bone disorder
Cardiomegaly (increased size of heart than normal)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Chest pain
Asthenia (weakness)
Neuropathy peripheral (surface nerve damage)
Injury

What are the common drug interactions of Aredia and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Anaemia (lack of blood)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve disease
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bladder cancer
Bone disorder

30-39:

Pharyngeal haemorrhage (pharyngeal bleeding)
Pharyngolaryngeal pain
Pneumonia
Abdominal pain upper
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Non-small cell lung cancer (type of epithelial lung cancer)
Oesophageal pain
Throat irritation

40-49:

Dyskinesia (abnormality or impairment of voluntary movement)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Dystonia (abnormal muscle tone)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Family stress
Injury
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting

50-59:

Osteonecrosis of jaw (death of bone of jaw)
Dental caries
Sensitivity of teeth
Anaemia (lack of blood)
Neoplasm malignant (cancer tumour)
Chest pain
Hyperlipidaemia (presence of excess lipids in the blood)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Back pain
Depression

60+:

Anxiety
Pain
Back pain
Pain in jaw
Dizziness
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Loss of consciousness
Abdominal pain

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 31 people, 40.79%
Multiple Myeloma (cancer of the plasma cells): 25 people, 32.89%
Breast Cancer Metastatic: 13 people, 17.11%
Seasonal Allergy (allergic condition due to certain season): 11 people, 14.47%
Type 2 Diabetes: 8 people, 10.53%
Osteoporosis (bones weak and more likely to break): 5 people, 6.58%

* Approximation only. Some reports may have incomplete information.

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