Aricept and Akineton drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aricept (donepezil hydrochloride) and Akineton (biperiden hydrochloride). Common drug interactions include dystonia among females and neuroleptic malignant syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Aricept and Akineton. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

What is Akineton?

Akineton has active ingredients of biperiden hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 6,140 Akineton users. Check the latest studies of Akineton.

On Jul, 29, 2026

32 people who take Aricept and Akineton together, and have interactions are studied.

What are the common drug interactions of Aricept and Akineton, by gender? *:

female:

Dystonia (abnormal muscle tone)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Cardiac failure
Confusional state
Delirium (wild excitement)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
General physical health deterioration (weak health status)
Nausea (feeling of having an urge to vomit)

male:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pneumonia
Hyperglycaemia (high blood sugar)
Loss of consciousness
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Pneumonitis aspiration (acute lung injury after the inhalation of regurgitated gastric contents)
Pyrexia (fever)
Respiratory depression (respiration has a rate below 12 breaths)
Respiratory failure (inadequate gas exchange by the respiratory system)
White blood cells urine positive

What are the common drug interactions of Aricept and Akineton, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pneumonia
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Cardiac failure
Coma (state of unconsciousness lasting more than six hours)
Confusional state
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)

What are the existing conditions these people have? *

Dementia (madness): 13 people, 40.62%
High Blood Pressure: 10 people, 31.25%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 6 people, 18.75%
Constipation: 4 people, 12.50%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 9.38%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 9.38%
Depression: 3 people, 9.38%
Insomnia (sleeplessness): 2 people, 6.25%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 6.25%
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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