Aricept and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aricept (donepezil hydrochloride) and Medrol (methylprednisolone). Common drug interactions include dermatitis contact among females and post transplant lymphoproliferative disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Aricept and Medrol. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

On Jul, 12, 2026

41 people who take Aricept and Medrol together, and have interactions are studied.

What are the common drug interactions of Aricept and Medrol, by gender? *:

female:

Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diastolic dysfunction
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dysarthria (speech disorder)
Dyslipidaemia (abnormal amount of lipids)
Dyspepsia (indigestion)
Dyspnoea exertional (breathlessness or shortness of breath)
Embolic stroke (stroke due to obstruction due to an embolus)
Emotional disorder
Excoriation (to tear or wear off the skin of)

male:

Post transplant lymphoproliferative disorder
Dyspnoea (difficult or laboured respiration)
Scrotal infection (infection in scrotum area)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Anal abscess
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Death
Delirium (wild excitement)
Gastroenteritis staphylococcal (inflammation of stomach and intestine caused by staphylococcal infection)

What are the common drug interactions of Aricept and Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasopharyngitis (inflammation of the nasopharynx)

30-39:

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)

40-49:

n/a

50-59:

Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nerve injury
Pain
Rectal abscess (pus in rectum)
Scar
Scrotal infection (infection in scrotum area)
Anal abscess

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Asthenia (weakness)
Loss of consciousness
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased)
Abasia (inability to walk)
Aphasia (damage to the parts of the brain that control language)
Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Haemorrhage intracranial (bleeding within the skull)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the existing conditions these people have? *

Pain: 9 people, 21.95%
Parkinson's Disease: 6 people, 14.63%
Osteoporosis (bones weak and more likely to break): 6 people, 14.63%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 6 people, 14.63%
High Blood Pressure: 5 people, 12.20%
Insomnia (sleeplessness): 4 people, 9.76%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 9.76%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 7.32%
Nausea (feeling of having an urge to vomit): 3 people, 7.32%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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