Sodium bicarbonate and Ozempic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sodium bicarbonate (sodium bicarbonate) and Ozempic (semaglutide). Common drug interactions include decreased appetite among females and blood calcium increased among males.

The phase IV clinical study analyzes what interactions people have when they take Sodium bicarbonate and Ozempic. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Sodium bicarbonate?

Sodium bicarbonate has active ingredients of sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 27,283 Sodium bicarbonate users. Check the latest studies of Sodium bicarbonate.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,761 Ozempic users. Check the latest studies of Ozempic.



On Jul, 12, 2026

37 people who take Sodium bicarbonate and Ozempic together, and have interactions are studied.

Sodium bicarbonate and Ozempic drug interactions.

What are the common drug interactions of Sodium Bicarbonate and Ozempic, by gender? *:

female:

  1. Decreased appetite
  2. Diarrhoea
  3. Renal impairment (severely reduced kidney function)
  4. Weight decreased
  5. Sepsis (a severe blood infection that can lead to organ failure and death)
  6. Aphasia (damage to the parts of the brain that control language)
  7. Arthralgia (joint pain)
  8. Back pain
  9. Chronic kidney disease
  10. Confusional state

male:

  1. Blood calcium increased
  2. Blood glucose decreased
  3. Decreased appetite
  4. Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
  5. Dizziness
  6. Dysgeusia (disorder of the sense of taste)
  7. Fatigue (feeling of tiredness)
  8. Localised infection (infection at the single location)
  9. Oedema peripheral (superficial swelling)
  10. Abdominal discomfort

What are the common drug interactions of Sodium Bicarbonate and Ozempic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Dizziness
  2. Lipohypertrophy (a lump under the skin caused by accumulation of extra fat at the site of many subcutaneous injections of insulin)
  3. Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

  1. Contusion (a type of hematoma of tissue in which capillaries)
  2. Renal impairment (severely reduced kidney function)

40-49:

  1. Chronic kidney disease
  2. Dizziness
  3. Nephrogenic anaemia (anaemia due to kidney disease)
  4. Oedema peripheral (superficial swelling)
  5. Renal failure (kidney dysfunction)
  6. Renal tubular necrosis (death of kidney tubules)

50-59:

  1. Sepsis (a severe blood infection that can lead to organ failure and death)
  2. Angina pectoris (chest pain due to ischemia of the heart muscle)
  3. Blindness unilateral
  4. Retinopathy (acute damage to the retina of the eye)
  5. Visual impairment

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Blood calcium increased
  3. Abdominal discomfort
  4. Aphasia (damage to the parts of the brain that control language)
  5. Arthralgia (joint pain)
  6. Asthenia (weakness)
  7. Back pain
  8. Blood pressure increased
  9. Catheter site infection (infection at the site of insertion)
  10. Confusional state

What are the existing conditions these people have? *

  1. Type 2 Diabetes: 11 people, 29.73%
  2. High Blood Cholesterol: 7 people, 18.92%
  3. Diabetes: 6 people, 16.22%
  4. Renal Disorder (kidney disease): 5 people, 13.51%
  5. Blood Calcium Decreased: 5 people, 13.51%
  6. High Blood Pressure: 5 people, 13.51%
  7. Erection Problems: 5 people, 13.51%
  8. Blood Glucose Abnormal: 4 people, 10.81%
  9. Multiple Myeloma (cancer of the plasma cells): 3 people, 8.11%
  10. Iga Nephropathy (kidney disease- condition prevents the kidneys from filtering waste): 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

Do you take Sodium bicarbonate and Ozempic?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sodium bicarbonate and Ozempic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sodium bicarbonate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ozempic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sodium bicarbonate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ozempic and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on sodium bicarbonate and semaglutide (the active ingredients of Sodium bicarbonate and Ozempic, respectively), and Sodium bicarbonate and Ozempic (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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