Aricept and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aricept (donepezil hydrochloride) and Prolia (denosumab). Common drug interactions include urinary retention among females and nasopharyngitis among males.

The phase IV clinical study analyzes what interactions people have when they take Aricept and Prolia. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

On Jul, 12, 2026

100 people who take Aricept and Prolia together, and have interactions are studied.

What are the common drug interactions of Aricept and Prolia, by gender? *:

female:

Urinary retention (the inability to completely or partially empty the bladder)
Vision blurred
Visual acuity reduced (reduced clearness of vision)
Visual impairment
Dizziness
Balance disorder
Death
Pain in extremity
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dry skin

male:

Nasopharyngitis (inflammation of the nasopharynx)
Back pain
Metastases to bone (cancer spreads to bone)
Pneumonia
Pulmonary mass
Renal failure (kidney dysfunction)
Respiratory disorder (respiratory disease)
Weight decreased
Chronic kidney disease
Decreased appetite

What are the common drug interactions of Aricept and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Dizziness
Death
Vulvovaginal injury
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Diarrhoea
Pain
Pneumonia
Urinary tract infection
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Senile dementia (memory loss with ageing)

What are the existing conditions these people have? *

Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 24 people, 24.00%
Pain: 15 people, 15.00%
High Blood Pressure: 10 people, 10.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 8.00%
Spinal Osteoarthritis (joint cartilage loss in spine): 7 people, 7.00%
Primary Myelofibrosis (primary disorder of the bone marrow): 7 people, 7.00%
Neuropathy Peripheral (surface nerve damage): 6 people, 6.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 6.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 6.00%
High Blood Cholesterol: 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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