Aricept and Trintellix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aricept (donepezil hydrochloride) and Trintellix (vortioxetine hydrobromide). Common drug interactions include facial paralysis among females and general physical health deterioration among males.

The phase IV clinical study analyzes what interactions people have when they take Aricept and Trintellix. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Aricept?

Aricept has active ingredients of donepezil hydrochloride. It is often used in alzheimer's disease. eHealthMe is studying from 24,756 Aricept users. Check the latest studies of Aricept.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

On Jul, 08, 2026

38 people who take Aricept and Trintellix together, and have interactions are studied.

Aricept and Trintellix drug interactions.

What are the common drug interactions of Aricept and Trintellix, by gender? *:

female:

Facial paralysis (loss of function of face muscle)
Herpes zoster
Hypoacusis (loss of hearing)
Influenza
Insomnia (sleeplessness)
Joint stiffness
Overdose
Pancreatitis (inflammation of pancreas)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Pyrexia (fever)

male:

General physical health deterioration (weak health status)
Decreased appetite
Hyperhidrosis (abnormally increased sweating)
Loss of consciousness
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Agitation (state of anxiety or nervous excitement)
Anxiety
Apnoea (suspension of external breathing)
Asthenia (weakness)
Death

What are the common drug interactions of Aricept and Trintellix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

50-59:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Anxiety
Death
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Gait disturbance
International normalised ratio increased
Parkinson's disease
Renal disorder (kidney disease)
Weight decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

Parkinson's Disease: 5 people, 13.16%
Bladder Disorder: 4 people, 10.53%
Infection: 4 people, 10.53%
Sleep Disorder: 4 people, 10.53%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 4 people, 10.53%
Hypersensitivity: 4 people, 10.53%
Dementia (madness): 3 people, 7.89%
High Blood Cholesterol: 3 people, 7.89%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 7.89%
Urinary Tract Infection: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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