Aripiprazole and Hydrodiuril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aripiprazole (aripiprazole) and Hydrodiuril (hydrochlorothiazide). Common drug interactions include ankle fracture among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Aripiprazole and Hydrodiuril. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Aripiprazole?

Aripiprazole has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 39,143 Aripiprazole users. Check the latest studies of Aripiprazole.

What is Hydrodiuril?

Hydrodiuril has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,211 Hydrodiuril users. Check the latest studies of Hydrodiuril.



On Jul, 17, 2026

18 people who take Aripiprazole and Hydrodiuril together, and have interactions are studied.

Aripiprazole and Hydrodiuril drug interactions.

What are the common drug interactions of Aripiprazole and Hydrodiuril, by gender? *:

female:

  1. Ankle fracture
  2. Anxiety
  3. Bone density decreased
  4. Dehydration (dryness resulting from the removal of water)
  5. Dyspnoea (difficult or laboured respiration)
  6. Emotional distress
  7. Hand fracture
  8. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
  9. Lactic acidosis (low ph in body tissues)
  10. Muscular weakness (muscle weakness)

male:

  1. Hospitalisation
  2. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the common drug interactions of Aripiprazole and Hydrodiuril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Hospitalisation
  2. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Ankle fracture
  3. Anxiety
  4. Bone density decreased
  5. Emotional distress
  6. Hand fracture
  7. Muscular weakness (muscle weakness)
  8. Osteoporosis (bones weak and more likely to break)
  9. Pain

50-59:

  1. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Lactic acidosis (low ph in body tissues)
  4. Pancreatitis acute (sudden inflammation of pancreas)
  5. Renal failure acute (rapid kidney dysfunction)

60+:

  1. Hypocalcaemia (levels of calcium in blood serum are abnormally low)
  2. Blood creatinine increased
  3. Rash generalised (rash on most of body parts)
  4. Wheezing (a high-pitched whistling sound made while you breath)
  5. Blood creatine phosphokinase increased
  6. Abdominal distension
  7. Asthenia (weakness)
  8. Decreased appetite
  9. Delirium (wild excitement)
  10. Hypophagia (reduced food intake)

What are the existing conditions these people have? *

  1. Pain: 10 people, 55.56%
  2. Neck Pain: 6 people, 33.33%
  3. Joint Pain: 6 people, 33.33%
  4. Post Laminectomy Syndrome: 6 people, 33.33%
  5. Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back)): 6 people, 33.33%
  6. Neuralgia (pain in one or more nerves): 6 people, 33.33%
  7. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 22.22%
  8. Hypoparathyroidism (inadequate secretion of parathyroid hormone resulting in abnormally low levels of calcium in the blood): 4 people, 22.22%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 22.22%
  10. Cough: 4 people, 22.22%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Aripiprazole and Hydrodiuril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aripiprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Hydrodiuril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aripiprazole and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydrodiuril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on aripiprazole and hydrochlorothiazide (the active ingredients of Aripiprazole and Hydrodiuril, respectively), and Aripiprazole and Hydrodiuril (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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