Arixtra and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arixtra (fondaparinux sodium) and Ultram (tramadol hydrochloride). Common drug interactions include pneumonia among females and hip fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Arixtra and Ultram. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Arixtra?

Arixtra has active ingredients of fondaparinux sodium. It is often used in deep venous thrombosis. eHealthMe is studying from 9,830 Arixtra users. Check the latest studies of Arixtra.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 14, 2026

25 people who take Arixtra and Ultram together, and have interactions are studied.

What are the common drug interactions of Arixtra and Ultram, by gender? *:

female:

Pneumonia
Arthralgia (joint pain)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Pain in extremity
Peripheral swelling
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Dyspnoea (difficult or laboured respiration)
Chest pain
Drug intolerance (drug sensitivity)
Hypotension (abnormally low blood pressure)

male:

Hip fracture
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Death
Dyspnoea (difficult or laboured respiration)
Gangrene (body tissue dies)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Groin pain
Heparin-induced thrombocytopenia
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Arixtra and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chest pain
Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)
Accidental needle stick

50-59:

Arthralgia (joint pain)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Pain in extremity
Peripheral swelling
Pneumonia
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Activated partial thromboplastin time prolonged
Anaemia (lack of blood)
Catheter related complication
Coagulation time prolonged

60+:

Nausea (feeling of having an urge to vomit)
Hip fracture
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Abdominal discomfort
Atelectasis (partial or complete collapse of the lung)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 5 people, 20.00%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 16.00%
Insomnia (sleeplessness): 3 people, 12.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 8.00%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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