Armodafinil and Wakix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Armodafinil (armodafinil) and Wakix (pitolisant hydrochloride). Common drug interactions include rib fracture among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Armodafinil and Wakix. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Armodafinil?

Armodafinil has active ingredients of armodafinil. It is often used in narcolepsy. eHealthMe is studying from 4,136 Armodafinil users. Check the latest studies of Armodafinil.

What is Wakix?

Wakix has active ingredients of pitolisant hydrochloride. eHealthMe is studying from 1,982 Wakix users. Check the latest studies of Wakix.

On Jul, 06, 2026

96 people who take Armodafinil and Wakix together, and have interactions are studied.

Armodafinil and Wakix drug interactions.

What are the common drug interactions of Armodafinil and Wakix, by gender? *:

female:

Rib fracture
Abortion spontaneous (naturally occurring miscarriage)
Blood pressure increased
Concussion (short loss of normal brain function in response to a head injury)
Disability
Drug hypersensitivity
Feeling jittery
Fractured coccyx (fracture tail bone)
Migraine (headache)
Palpitations (feelings or sensations that your heart is pounding or racing)

male:

Anxiety
Weight decreased
Fatigue (feeling of tiredness)
Headache (pain in head)
Colitis ulcerative (inflammation of colon with ulcer)
Decreased appetite
Feeling jittery
Hyperthyroidism (over activity of the thyroid gland)
Mood altered (changes in mood)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Armodafinil and Wakix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dizziness
Drug ineffective
Panic attack
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

20-29:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Hypersensitivity
Drug ineffective
Dizziness
Initial insomnia (feeling of inadequate or poor-quality sleep)
Palpitations (feelings or sensations that your heart is pounding or racing)
Suicidal ideation
Panic attack
Cardiac murmur (an heart sound in valve abnormality)
Dissociation

30-39:

Palpitations (feelings or sensations that your heart is pounding or racing)
Pruritus (severe itching of the skin)
Rash
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Serum ferritin decreased
Swelling face
Fatigue (feeling of tiredness)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Depression
Drug hypersensitivity

40-49:

Hypertension (high blood pressure)
Essential hypertension (primary hypertension)
Hot flush (sudden feelings of heat)
Anaemia (lack of blood)
Anxiety
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Depression
Dizziness postural
Dyspnoea exertional (breathlessness or shortness of breath)
Fall

50-59:

Enuresis (repeated inability to control urination)

60+:

Headache (pain in head)
Surgery
Prostatic disorder
Restless legs syndrome (a powerful urge to move your legs)
Sleep paralysis (waking up and unable to move or speak)
Vomiting
Asthma
Concussion (short loss of normal brain function in response to a head injury)
Confusional state
Decreased appetite

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 56 people, 58.33%
Drowsiness: 49 people, 51.04%

* Approximation only. Some reports may have incomplete information.

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