Arthrotec and Divalproex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Arthrotec (diclofenac sodium; misoprostol) and Divalproex (divalproex sodium). Common drug interactions include abdominal pain among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Arthrotec and Divalproex. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Arthrotec?

Arthrotec has active ingredients of diclofenac sodium; misoprostol. It is often used in arthritis. eHealthMe is studying from 11,986 Arthrotec users. Check the latest studies of Arthrotec.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

On Jul, 29, 2026

19 people who take Arthrotec and Divalproex together, and have interactions are studied.

Arthrotec and Divalproex drug interactions.

What are the common drug interactions of Arthrotec and Divalproex, by gender? *:

female:

Abdominal pain
Hepatitis (inflammation of the liver)
Hepatomegaly (abnormal enlargement of the liver)
Asthenia (weakness)
Atrophy (wasting away of a part of the body)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Depression
Joint effusion (presence of extra fluid in joint covering)
Muscle spasms (muscle contraction)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)

male:

Chronic kidney disease
Diarrhoea
Dyspepsia (indigestion)
Hepatic failure (liver failure)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)

What are the common drug interactions of Arthrotec and Divalproex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Hepatitis (inflammation of the liver)
Hepatomegaly (abnormal enlargement of the liver)
Hepatic failure (liver failure)
Renal failure acute (rapid kidney dysfunction)

50-59:

Depression
Fall
Insomnia (sleeplessness)
Joint effusion (presence of extra fluid in joint covering)
Muscle spasms (muscle contraction)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoporosis (bones weak and more likely to break)
Panic reaction
Psychogenic pain disorder
Social avoidant behaviour (avoiding social connection a personality disorder)

60+:

Chronic kidney disease
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Pain: 5 people, 26.32%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 21.05%
Back Pain: 3 people, 15.79%
Menopause (end of monthly cycles in women): 3 people, 15.79%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.53%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 10.53%
Drowsiness: 2 people, 10.53%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 10.53%
Diabetes: 1 person, 5.26%
Depression: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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