Aspirin and Kuvan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aspirin (aspirin) and Kuvan (sapropterin dihydrochloride). Common drug interactions include maternal exposure during pregnancy among females and amino acid level increased among males.

The phase IV clinical study analyzes what interactions people have when they take Aspirin and Kuvan. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Aspirin?

Aspirin has active ingredients of aspirin. It is often used in blood clots. eHealthMe is studying from 632,088 Aspirin users. Check the latest studies of Aspirin.

What is Kuvan?

Kuvan has active ingredients of sapropterin dihydrochloride. It is often used in phenylketonuria. eHealthMe is studying from 5,732 Kuvan users. Check the latest studies of Kuvan.

On Jul, 16, 2026

33 people who take Aspirin and Kuvan together, and have interactions are studied.

What are the common drug interactions of Aspirin and Kuvan, by gender? *:

female:

Maternal exposure during pregnancy (use of substance during pregnancy)
Pharyngeal haemorrhage (pharyngeal bleeding)
Agitation (state of anxiety or nervous excitement)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Glaucoma (increased fluid pressure in the eye with vision loss)
Hunger
Migraine (headache)
Nausea (feeling of having an urge to vomit)

male:

Amino acid level increased
Cough
Left ventricular failure (left ventricle fails to contract forcefully)
Abdominal pain upper
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Increased appetite
Weight increased

What are the common drug interactions of Aspirin and Kuvan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal discomfort
Acute respiratory distress syndrome
Blindness
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Fatigue (feeling of tiredness)
Hyperchlorhydria (gastric acid levels are higher in stomach)
Hypoacusis (loss of hearing)
Infection
Inflammation
Oesophageal dysplasia (abnormality of oesophagus development)

20-29:

Fatigue (feeling of tiredness)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Thirst

30-39:

n/a

40-49:

Chest discomfort
Dyspnoea (difficult or laboured respiration)
Glaucoma (increased fluid pressure in the eye with vision loss)
Hunger
Migraine (headache)
Visual acuity reduced (reduced clearness of vision)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pharyngeal haemorrhage (pharyngeal bleeding)
Arthralgia (joint pain)
Ear congestion

50-59:

Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Cardiac arrest
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

60+:

Left ventricular failure (left ventricle fails to contract forcefully)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Death
Gastric disorder (disease of stomach)

What are the existing conditions these people have? *

Pain: 3 people, 9.09%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 9.09%
High Blood Cholesterol: 2 people, 6.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.06%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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