Astelin and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Astelin (azelastine hydrochloride) and Vytorin (ezetimibe; simvastatin). Common drug interactions include insomnia among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Astelin and Vytorin. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Astelin?

Astelin has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 5,538 Astelin users. Check the latest studies of Astelin.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

On Jul, 12, 2026

86 people who take Astelin and Vytorin together, and have interactions are studied.

What are the common drug interactions of Astelin and Vytorin, by gender? *:

female:

Insomnia (sleeplessness)
Pain
Vomiting
Weight increased
Arthralgia (joint pain)
Blood glucose increased
Constipation
Injury
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Biliary dilatation

male:

Back pain
Pain
Headache (pain in head)
Hepatic enzyme increased
Hepatitis (inflammation of the liver)
Hyperhidrosis (abnormally increased sweating)
Influenza
Myalgia (muscle pain)
Nasal discomfort
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Astelin and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Insomnia (sleeplessness)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Blood sodium increased
Constipation
Hemiplegic migraine (migraine attacks occurring in two or more people in the same family who experience weakness on one side of body)
Lymphocytic hypophysitis (inflammation of the pituitary gland)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Pituitary tumour benign
Polyuria (production of too much dilute urine)
Proteinuria (presence of protein in the urine)

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Cardiomyopathy (weakening of the heart muscle)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Emotional distress
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Mobility decreased (ability to move is reduced)

50-59:

Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthenia (weakness)
Chest discomfort
Chills (felling of cold)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hepatic enzyme increased
Hepatitis (inflammation of the liver)

60+:

Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)
Depression
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Vomiting
Weight decreased
Haematuria (presence of blood in urine)
Pyrexia (fever)
Urinary tract infection

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 10.47%
Sinusitis (inflammation of sinus): 8 people, 9.30%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 8.14%
Hypersensitivity: 7 people, 8.14%
Asthma: 6 people, 6.98%
Allergic Rhinitis: 6 people, 6.98%
Pain: 5 people, 5.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.81%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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