Atarax and Nexavar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Atarax (hydroxyzine hydrochloride) and Nexavar (sorafenib tosylate). Common drug interactions include acute respiratory failure among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Atarax and Nexavar. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Atarax?

Atarax has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 23,553 Atarax users. Check the latest studies of Atarax.

What is Nexavar?

Nexavar has active ingredients of sorafenib tosylate. It is often used in hepatocellular carcinoma. eHealthMe is studying from 23,250 Nexavar users. Check the latest studies of Nexavar.

On Jul, 29, 2026

70 people who take Atarax and Nexavar together, and have interactions are studied.

What are the common drug interactions of Atarax and Nexavar, by gender? *:

female:

Acute respiratory failure
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure increased
Body temperature increased
Catheter site pain
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Chills (felling of cold)
Dry skin
Ear pain

male:

Diarrhoea
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Decreased appetite
Hypertension (high blood pressure)
Haemoglobin decreased
Pleural effusion (water on the lungs)
Ascites (accumulation of fluid in the abdominal cavity)
Respiratory failure (inadequate gas exchange by the respiratory system)
White blood cell count decreased
Cough

What are the common drug interactions of Atarax and Nexavar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure increased
Body temperature increased
Catheter site pain
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Chills (felling of cold)
Diarrhoea
Dry skin
Ear pain

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Blood amylase increased
Constipation
Amylase increased
Platelet count decreased
Haematuria (presence of blood in urine)
Pleural effusion (water on the lungs)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)

60+:

Diarrhoea
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pyrexia (fever)
White blood cell count decreased
Cough
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Dyspepsia (indigestion)
Hepatic neoplasm malignant (liver cancer)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the existing conditions these people have? *

Hepatic Neoplasm Malignant (liver cancer): 26 people, 37.14%
Renal Cell Carcinoma Stage Iv (stage iv renal cell cancer have cancer that has spread to other organs, such as the lungs, liver, bones, or brain, and may have spread to lymph nodes): 15 people, 21.43%
Renal Cell Carcinoma (a kidney cancer): 14 people, 20.00%
Pain: 9 people, 12.86%
Insomnia (sleeplessness): 9 people, 12.86%
Constipation: 9 people, 12.86%
Itching: 7 people, 10.00%
High Blood Pressure: 5 people, 7.14%
Palmar-Plantar Erythrodysaesthesia Syndrome (hand-foot syndrome): 4 people, 5.71%
Nausea (feeling of having an urge to vomit): 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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