Atripla and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Atripla (efavirenz; emtricitabine; tenofovir disoproxil fumarate) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include anhedonia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Atripla and Adderall. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Atripla?

Atripla has active ingredients of efavirenz; emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 36,036 Atripla users. Check the latest studies of Atripla.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,225 Adderall users. Check the latest studies of Adderall.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

64 people who take Atripla and Adderall together, and have interactions are studied.

What are the common drug interactions of Atripla and Adderall, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Quality of life decreased
Blood creatinine increased
Impaired work ability

male:

Anxiety
Emotional distress
Blood creatinine increased
Fatigue (feeling of tiredness)
Tooth loss
Wrist fracture
Arthralgia (joint pain)
Skeletal injury (bone and supporting muscle injury)
Bone pain
Back pain

What are the common drug interactions of Atripla and Adderall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Bone density decreased
Osteoporosis (bones weak and more likely to break)
Renal failure (kidney dysfunction)
Discomfort
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Injury

30-39:

Blood urine present
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Glycosuria (excretion of glucose into the urine)
Multiple injuries
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Rib fracture
Skeletal injury (bone and supporting muscle injury)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Wrist fracture

40-49:

Anxiety
Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Ankle fracture
Arthralgia (joint pain)
Bone pain
Fatigue (feeling of tiredness)
Gait disturbance

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Bone density decreased
Ankle fracture
Chronic kidney disease
Multiple fractures
Renal failure (kidney dysfunction)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Bone density decreased
Ankle fracture
Lower limb fracture
Osteomalacia (softening of the bones due to a lack of vitamin d)
Protein urine present
Renal impairment (severely reduced kidney function)
Spinal fracture (fracture in one of vertebrae)

What are the existing conditions these people have? *

Stress And Anxiety: 8 people, 12.50%
High Blood Pressure: 6 people, 9.38%
Depression: 6 people, 9.38%
Pain: 5 people, 7.81%
Insomnia (sleeplessness): 5 people, 7.81%
Back Pain: 5 people, 7.81%
Neuralgia (pain in one or more nerves): 4 people, 6.25%
Muscle Spasms (muscle contraction): 4 people, 6.25%
Hypersensitivity: 4 people, 6.25%
Allergic Rhinitis: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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