Atripla and Valacyclovir hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Atripla (efavirenz; emtricitabine; tenofovir disoproxil fumarate) and Valacyclovir hydrochloride (valacyclovir hydrochloride). Common drug interactions include joint swelling among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Atripla and Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Atripla?

Atripla has active ingredients of efavirenz; emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 36,036 Atripla users. Check the latest studies of Atripla.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

On Jul, 09, 2026

54 people who take Atripla and Valacyclovir hydrochloride together, and have interactions are studied.

Atripla and Valacyclovir hydrochloride drug interactions.

What are the common drug interactions of Atripla and Valacyclovir Hydrochloride, by gender? *:

female:

Joint swelling
Skeletal injury (bone and supporting muscle injury)
Chronic kidney disease
Mobility decreased (ability to move is reduced)
Renal failure (kidney dysfunction)
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Arthropathy
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Anaemia (lack of blood)
Ankle fracture

male:

Anxiety
Pain
Foot fracture
Hypertension (high blood pressure)
Blood creatinine increased
Mobility decreased (ability to move is reduced)
Quality of life decreased
Bone density decreased
Osteomalacia (softening of the bones due to a lack of vitamin d)
Insomnia (sleeplessness)

What are the common drug interactions of Atripla and Valacyclovir Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Fatigue (feeling of tiredness)
Glomerulosclerosis (a hardening of the glomerulus in the kidney)
Hypertension (high blood pressure)
Immune system disorder
Mobility decreased (ability to move is reduced)
Pain
Renal impairment (severely reduced kidney function)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Pain
Hypertension (high blood pressure)
Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Blood creatinine increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

40-49:

Foot fracture
Decreased activity
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Nephrogenic anaemia (anaemia due to kidney disease)
Osteomalacia (softening of the bones due to a lack of vitamin d)
Bone disorder
Impaired work ability
Bone density decreased
Gait disturbance

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Multiple fractures
Back pain
Gait disturbance
Joint range of motion decreased (disease of joint movement)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthropathy
Fear
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Chronic kidney disease
Foot fracture
Ankle fracture

What are the existing conditions these people have? *

Pain: 5 people, 9.26%
High Blood Pressure: 4 people, 7.41%
Viral Infection: 3 people, 5.56%
Fungal Infection: 3 people, 5.56%
Erection Problems: 3 people, 5.56%
Bacterial Infection: 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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