Augmentin and Actemra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Augmentin (amoxicillin; clavulanate potassium) and Actemra (tocilizumab). Common drug interactions include gastric ulcer among females and agranulocytosis among males.

The phase IV clinical study analyzes what interactions people have when they take Augmentin and Actemra. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

What is Actemra?

Actemra has active ingredients of tocilizumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 102,759 Actemra users. Check the latest studies of Actemra.

On Aug, 04, 2026

41 people who take Augmentin and Actemra together, and have interactions are studied.

Augmentin and Actemra drug interactions.

What are the common drug interactions of Augmentin and Actemra, by gender? *:

female:

Gastric ulcer (stomach ulcer)
Gingival pain (gum pain)
Headache (pain in head)
Hepatocellular injury (liver injury)
Hospitalisation
Hydronephrosis (water inside the kidney)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Dyspnoea (difficult or laboured respiration)
Rash

male:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Gingivitis (inflammation of gums)
Gastrointestinal perforation (hole in the digestive tract)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Left ventricular dysfunction
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Pyrexia (fever)

What are the common drug interactions of Augmentin and Actemra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Blood creatinine increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Left ventricular dysfunction
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Pyrexia (fever)

10-19:

n/a

20-29:

Eye infection
Otitis media (inflammation of the middle ear)
Upper respiratory tract infection

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Maternal exposure during pregnancy (use of substance during pregnancy)

40-49:

Disability
Hypoxia (low oxygen in tissues)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory disorder (respiratory disease)
Dyspnoea (difficult or laboured respiration)
Gingivitis (inflammation of gums)
Meningioma (a diverse set of tumours arising from the meninges)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Interstitial lung disease
Pneumonia

50-59:

Leukopenia (less number of white blood cells in blood)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Blood pressure increased
Depression
Fatigue (feeling of tiredness)
Haematochezia (passage of stools containing blood)
Rash
Abdominal mass (localized enlargement or swelling in the human abdomen)
Abdominal pain
Ankle fracture

60+:

Rash
Back pain
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Cheilitis (infection of lips)
Cough
Cushingoid (obesity and weakening of the muscles)
Dehydration (dryness resulting from the removal of water)
Drug effect decreased
Ear injury
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)

What are the existing conditions these people have? *

Upper Gastrointestinal Haemorrhage (upper gastrointestinal bleeding): 3 people, 7.32%
Temporal Arteritis (inflammation and damage to blood vessels that supply the head area): 3 people, 7.32%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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