Avalide and Ampyra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avalide (hydrochlorothiazide; irbesartan) and Ampyra (dalfampridine). Common drug interactions include acute coronary syndrome among females and balance disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Avalide and Ampyra. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

What is Ampyra?

Ampyra has active ingredients of dalfampridine. It is often used in multiple sclerosis. eHealthMe is studying from 77,145 Ampyra users. Check the latest studies of Ampyra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

19 people who take Avalide and Ampyra together, and have interactions are studied.

What are the common drug interactions of Avalide and Ampyra, by gender? *:

female:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Cardiac failure congestive
Injury
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Urinary tract infection
Fall
Blood creatinine increased
Fatigue (feeling of tiredness)
Pain in extremity

male:

Balance disorder
Drug ineffective
Muscular weakness (muscle weakness)
Asthenia (weakness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Dysarthria (speech disorder)
Insomnia (sleeplessness)
Pyrexia (fever)
Chest discomfort

What are the common drug interactions of Avalide and Ampyra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Cardiac failure congestive
Injury
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Pain in extremity
Asthenia (weakness)
Balance disorder
Concussion (short loss of normal brain function in response to a head injury)
Depressed mood

50-59:

Balance disorder
Chest discomfort
Dyskinesia (abnormality or impairment of voluntary movement)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Hypokinesia (decreased bodily movement)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Visual impairment
Asthenia (weakness)

60+:

Urinary tract infection
Fall
Joint dislocation (a joint position is changed from normal position)
Social problem
Chills (felling of cold)
Malaise (a feeling of general discomfort or uneasiness)
Oedema peripheral (superficial swelling)
Pain
Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

What are the existing conditions these people have? *

Gait Disturbance: 13 people, 68.42%
Upper Motor Neurone Lesion (lesion of the neural pathway above the anterior horn cell of the spinal cord or motor nuclei of the cranial nerves): 1 person, 5.26%
Type 2 Diabetes: 1 person, 5.26%
Muscle Spasms (muscle contraction): 1 person, 5.26%
Depression: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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