Profen and Injection site infection - a phase IV clinical study of FDA data

Summary:

Injection site infection is reported as a side effect among people who take Profen (ibuprofen), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Betaseron, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Injection site infection when taking Profen. It is created by eHealthMe based on reports of 239,319 people who have side effects when taking Profen from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

What is Injection site infection?

Injection site infection is found to be associated with 324 drugs and 401 conditions by eHealthMe. Check the latest studies of Injection site infection.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

239,319 people reported to have side effects when taking Profen.
Among them, 46 people (0.02%) have Injection site infection.

Could Profen cause Injection site infection?

Among these 46 people:

How long have people been on Profen when they have Injection site infection? *

What is the gender of people who have Injection site infection when taking Profen? *

female: 50 %
male: 50 %

What is the age of people who have Injection site infection when taking Profen? *

What are other drugs people take besides Profen? *

What are other side effects people have besides Injection site infection? *

Injection Site Erythema (redness at injection site): 12 people, 26.09%
Injection Site Mass: 10 people, 21.74%
Injection Site Pain: 10 people, 21.74%
Fever: 9 people, 19.57%
Muscle Spasms (muscle contraction): 7 people, 15.22%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 6 people, 13.04%
Fall: 6 people, 13.04%
Memory Loss: 5 people, 10.87%
Injection Site Swelling: 5 people, 10.87%
Mobility Decreased (ability to move is reduced): 5 people, 10.87%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 16 people, 34.78%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 4 people, 8.70%
Immunodeficiency Common Variable: 3 people, 6.52%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.52%
Gastric Ulcer (stomach ulcer): 3 people, 6.52%
Burnout Syndrome (problems related to life-management difficulty, but not considered a ""disorder): 2 people, 4.35%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 4.35%
Type 2 Diabetes: 2 people, 4.35%
Multiple Fractures: 2 people, 4.35%
Injection Site Nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site): 1 person, 2.17%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and have Injection site infection?

- Check whether Injection site infection is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Profen:

Profen (245,312 reports)

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site infection:

Injection site infection (324 drugs)

Browse all the conditions that are associated with Injection site infection:

Injection site infection (401 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Profen) and Profen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.