Avalide and Clonazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avalide (hydrochlorothiazide; irbesartan) and Clonazepam (clonazepam). Common drug interactions include malaise among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Avalide and Clonazepam. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

What is Clonazepam?

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,272 Clonazepam users. Check the latest studies of Clonazepam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

75 people who take Avalide and Clonazepam together, and have interactions are studied.

Avalide and Clonazepam drug interactions.

What are the common drug interactions of Avalide and Clonazepam, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Vomiting
Drug ineffective
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)
Blood alkaline phosphatase increased
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Pleural effusion (water on the lungs)

male:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Chills (felling of cold)
Hepatic enzyme increased
Hepatitis (inflammation of the liver)
Hyperhidrosis (abnormally increased sweating)
Influenza
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

What are the common drug interactions of Avalide and Clonazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abnormal behaviour
Aggression
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Chronic kidney disease
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Diabetic nephropathy (diabetic kidney disease)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hallucination (an experience involving the perception of something not present)

40-49:

Fall
Nausea (feeling of having an urge to vomit)
Depression
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal discomfort
Arthralgia (joint pain)
Back pain
Chest pain
Gait disturbance

50-59:

Depression
Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Back pain
Chest discomfort
Chills (felling of cold)
Hepatitis (inflammation of the liver)
Hyperhidrosis (abnormally increased sweating)
Hyperthyroidism (over activity of the thyroid gland)
Influenza

60+:

Fatigue (feeling of tiredness)
Headache (pain in head)
Platelet count decreased
Diarrhoea
Myalgia (muscle pain)
Pain
Haematocrit decreased
Haemoglobin decreased
Lymphocyte count decreased
Monocyte count increased

What are the existing conditions these people have? *

Pain: 15 people, 20.00%
Depression: 9 people, 12.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 12.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 9.33%
High Blood Cholesterol: 6 people, 8.00%
Osteoporosis (bones weak and more likely to break): 5 people, 6.67%
Sinusitis (inflammation of sinus): 5 people, 6.67%
Muscle Spasms (muscle contraction): 5 people, 6.67%
Infection: 5 people, 6.67%
Diabetes: 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

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