Avandamet and Valium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Avandamet (metformin hydrochloride; rosiglitazone maleate) and Valium (diazepam). Common drug interactions include balance disorder among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Avandamet and Valium. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Avandamet?

Avandamet has active ingredients of metformin hydrochloride; rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 16,084 Avandamet users. Check the latest studies of Avandamet.

What is Valium?

Valium has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 48,647 Valium users. Check the latest studies of Valium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

38 people who take Avandamet and Valium together, and have interactions are studied.

What are the common drug interactions of Avandamet and Valium, by gender? *:

female:

Balance disorder
Benign neoplasm of adrenal gland (benign (non-cancerous) tumours of the adrenal gland)
Breast mass
Conjunctivitis (pink eye)
Culture wound positive
Epistaxis (bleed from the nose)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
Gastric ulcer (stomach ulcer)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

male:

Cardiac disorder
Circulatory collapse
Hypertension (high blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Neuropathy peripheral (surface nerve damage)
Pericarditis (inflammation of the pericardium)
Cardiac failure congestive
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Irritability

What are the common drug interactions of Avandamet and Valium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Eye injury
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Hypoaesthesia (reduced sense of touch or sensation)
Irritability
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Neuropathy peripheral (surface nerve damage)

30-39:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Eye injury
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gestational diabetes (diabetes in pregnancy)
Hepatic enzyme increased
Hypoaesthesia (reduced sense of touch or sensation)
Irritability
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)

40-49:

Cardiac disorder
Circulatory collapse
Death
Sick sinus syndrome (a collection of heart rhythm disorders)
Arthropathy
Neuropathy peripheral (surface nerve damage)
Arrhythmia (irregular heartbeat)
Cluster headache (one-sided head pain with tearing)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Drug screen positive

50-59:

Blood glucose increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Enterococcal infection
Excoriation (to tear or wear off the skin of)
Hypertension (high blood pressure)
Impaired healing
Morganella infection (infection by morganella morganii bacteria)
Osteomyelitis (infection of bone)

60+:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Arterial disorder
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Ammonia increased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Aphasia (damage to the parts of the brain that control language)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting

What are the existing conditions these people have? *

Depression: 7 people, 18.42%
Type 2 Diabetes: 6 people, 15.79%
Nervousness: 6 people, 15.79%
Insomnia (sleeplessness): 6 people, 15.79%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 10.53%
Bipolar Disorder (mood disorder): 3 people, 7.89%
Sleep Disorder: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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