Axiron and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Axiron (testosterone) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include hypersensitivity among females and transient ischaemic attack among males.

The phase IV clinical study analyzes what interactions people have when they take Axiron and Flexeril. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Axiron?

Axiron has active ingredients of testosterone. It is often used in testosterone. eHealthMe is studying from 7,703 Axiron users. Check the latest studies of Axiron.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Aug, 12, 2026

36 people who take Axiron and Flexeril together, and have interactions are studied.

What are the common drug interactions of Axiron and Flexeril, by gender? *:

female:

Hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Mood swings (an extreme or rapid change in mood)
Acute myocardial infarction (acute heart attack)
Aggression
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Blood glucose increased
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Axiron and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Osteoporosis (bones weak and more likely to break)
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Skin burning sensation
Spinal compression fracture (fracture due to spinal compression on bone)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)

30-39:

n/a

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Thrombosis (formation of a blood clot inside a blood vessel)
Acute myocardial infarction (acute heart attack)
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Blood glucose increased
Chest pain
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diastolic dysfunction

50-59:

Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Protein s deficiency
Thrombosis (formation of a blood clot inside a blood vessel)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Malaise (a feeling of general discomfort or uneasiness)
Aggression
Chest pain
Hypersensitivity
Hypertensive heart disease

60+:

Deafness
Mood swings (an extreme or rapid change in mood)
Suicidal ideation
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Brain death
Cerebral haemorrhage (bleeding within the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coma (state of unconsciousness lasting more than six hours)
Depression
Diarrhoea

What are the existing conditions these people have? *

Blood Testosterone Decreased: 18 people, 50.00%
Pain: 12 people, 33.33%
Back Pain: 6 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 13.89%
High Blood Cholesterol: 5 people, 13.89%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 13.89%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 8.33%
Infection: 3 people, 8.33%
Hypersensitivity: 3 people, 8.33%
Diabetes: 3 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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