Azilect and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azilect (rasagiline mesylate) and Keppra (levetiracetam). Common drug interactions include hyperphagia among females and blood pressure decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Azilect and Keppra. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Azilect?

Azilect has active ingredients of rasagiline mesylate. It is often used in parkinson's disease. eHealthMe is studying from 8,622 Azilect users. Check the latest studies of Azilect.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

43 people who take Azilect and Keppra together, and have interactions are studied.

What are the common drug interactions of Azilect and Keppra, by gender? *:

female:

Hyperphagia (an abnormal appetite for food)
Loss of consciousness
Nonspecific reaction (unspecified reaction)
Oedema peripheral (superficial swelling)
Persecutory delusion
Pruritus (severe itching of the skin)
Speech disorder
Swelling
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Delusion (a false belief or opinion)

male:

Blood pressure decreased
Fall
Asthenia (weakness)
Dyskinesia (abnormality or impairment of voluntary movement)
Freezing phenomenon
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Cellulitis (infection under the skin)
Cough
Death

What are the common drug interactions of Azilect and Keppra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response unexpected

50-59:

Hyperglycaemia (high blood sugar)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Insomnia (sleeplessness)
Iron deficiency anaemia
Leukocytosis (increased white blood cells)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Normochromic normocytic anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits)
Restless legs syndrome (a powerful urge to move your legs)
Face oedema (swelling of face)

60+:

Fall
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection
Visual impairment
Wheezing (a high-pitched whistling sound made while you breath)
Cellulitis (infection under the skin)
Confusional state

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 13.95%
Dyskinesia (abnormality or impairment of voluntary movement): 6 people, 13.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.63%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 9.30%
High Blood Pressure: 4 people, 9.30%
Stable Angina (a constant chest pain): 3 people, 6.98%
On And Off Phenomenon: 3 people, 6.98%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 6.98%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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