Azilect and Norco drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azilect (rasagiline mesylate) and Norco (acetaminophen; hydrocodone bitartrate). Common drug interactions include peripheral swelling among females and adverse event among males.

The phase IV clinical study analyzes what interactions people have when they take Azilect and Norco. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Azilect?

Azilect has active ingredients of rasagiline mesylate. It is often used in parkinson's disease. eHealthMe is studying from 8,622 Azilect users. Check the latest studies of Azilect.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

On Jul, 13, 2026

20 people who take Azilect and Norco together, and have interactions are studied.

What are the common drug interactions of Azilect and Norco, by gender? *:

female:

Peripheral swelling
Hypersomnia (excessive daytime sleepiness (eds))
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Delusion (a false belief or opinion)
Fatigue (feeling of tiredness)
Lethargy (tiredness)
Psychotic disorder
Somnolence (a state of near-sleep, a strong desire for sleep)
Stiff person syndrome
Weight decreased

male:

Adverse event
Tremor (trembling or shaking movements in one or more parts of your body)
Blood pressure increased
Cough
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Device dislocation
Disease progression
Dysstasia (difficulty in standing)
Hypersomnia (excessive daytime sleepiness (eds))
Insomnia (sleeplessness)

What are the common drug interactions of Azilect and Norco, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hypersomnia (excessive daytime sleepiness (eds))
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)

60+:

Tremor (trembling or shaking movements in one or more parts of your body)
Death
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Delusion (a false belief or opinion)
Device dislocation
Disease progression
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Lethargy (tiredness)
Mobility decreased (ability to move is reduced)

What are the existing conditions these people have? *

Delusion (a false belief or opinion): 5 people, 25.00%
Hallucinations (sensations that appear real but are created by your mind): 5 people, 25.00%
On And Off Phenomenon: 4 people, 20.00%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 3 people, 15.00%
Constipation: 3 people, 15.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 10.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 10.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 10.00%
Depression: 2 people, 10.00%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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