Azithromycin and Emla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azithromycin (azithromycin) and Emla (lidocaine; prilocaine). Common drug interactions include oedema peripheral among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Azithromycin and Emla. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Azithromycin?

Azithromycin has active ingredients of azithromycin. It is often used in sinusitis. eHealthMe is studying from 40,716 Azithromycin users. Check the latest studies of Azithromycin.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

On Jul, 26, 2026

59 people who take Azithromycin and Emla together, and have interactions are studied.

Azithromycin and Emla drug interactions.

What are the common drug interactions of Azithromycin and Emla, by gender? *:

female:

Oedema peripheral (superficial swelling)
Erythema (redness of the skin)
Pain
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Pyrexia (fever)
Anxiety disorder
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chest discomfort
Drug dependence
Insomnia (sleeplessness)

male:

Anxiety
Nausea (feeling of having an urge to vomit)
Cough
Depression
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Impulse-control disorder
Lung neoplasm (tumour of lung)

What are the common drug interactions of Azithromycin and Emla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anger
Anxiety
Attention deficit/hyperactivity disorder
Autism spectrum disorder (developmental disabilities that can cause significant social, communication and behavioural challenges)
B-cell lymphoma (blood cancer affecting b cells)
Bipolar disorder (mood disorder)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Conjunctivitis (pink eye)
Cough
Depression

10-19:

Nasopharyngitis (inflammation of the nasopharynx)
Back pain
Cough
Dizziness
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)

20-29:

Eosinophil count increased

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Atrial thrombosis (blood clot that develops in an artery)
Emotional distress
General physical health deterioration (weak health status)
Injury
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Pain
Pelvic neoplasm (tumours or cancer of the pelvic region)
Thrombosis (formation of a blood clot inside a blood vessel)

40-49:

Mucosal inflammation (infection of mucous membrane)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Pain in jaw
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Sebaceous gland disorder (disease of oil gland of skin)
Spinal cord compression
Spinal osteoarthritis (joint cartilage loss in spine)
Swelling
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Anxiety disorder

50-59:

Chronic kidney disease
Erythema multiforme (a type of hypersensitivity reaction)
Febrile neutropenia (fever with reduced white blood cells)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Oedema peripheral (superficial swelling)
Rash follicular (redness of hair follicle)
Rash generalised (rash on most of body parts)
Renal failure (kidney dysfunction)
Skin desquamation (loss of the upper layers of skin)
Acute pulmonary oedema (sudden deposit of fluid in the lung))

60+:

Pyrexia (fever)
Hypotension (abnormally low blood pressure)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dyspnoea (difficult or laboured respiration)
Haematocrit decreased
Haemoglobin decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Platelet count decreased
Rhonchi (abnormal breath sounds)
Staphylococcal infection (an infection with staphylococcus bacteria)

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 14 people, 23.73%
Pain: 9 people, 15.25%
Nausea (feeling of having an urge to vomit): 6 people, 10.17%
Immunodeficiency Common Variable: 6 people, 10.17%
Infection: 5 people, 8.47%
Cough: 5 people, 8.47%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 6.78%
Multiple Myeloma (cancer of the plasma cells): 4 people, 6.78%
Nausea And Vomiting: 3 people, 5.08%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

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