Azulfidine and Motrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azulfidine (sulfasalazine) and Motrin (ibuprofen). Common drug interactions include cough among females and hepatic failure among males.

The phase IV clinical study analyzes what interactions people have when they take Azulfidine and Motrin. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Azulfidine?

Azulfidine has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis. eHealthMe is studying from 7,997 Azulfidine users. Check the latest studies of Azulfidine.

What is Motrin?

Motrin has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 38,332 Motrin users. Check the latest studies of Motrin.

On Jul, 17, 2026

28 people who take Azulfidine and Motrin together, and have interactions are studied.

Azulfidine and Motrin drug interactions.

What are the common drug interactions of Azulfidine and Motrin, by gender? *:

female:

Cough
Crying
Cushingoid (obesity and weakening of the muscles)
Cystitis (inflammation of the wall of the bladder)
Decreased activity
Dehydration (dryness resulting from the removal of water)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Influenza

male:

Hepatic failure (liver failure)
International normalised ratio increased
Hepatocellular damage (liver damage)
Renal failure (kidney dysfunction)
Activated partial thromboplastin time prolonged
Blood bilirubin increased
Skin infection
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lethargy (tiredness)
Loss of consciousness

What are the common drug interactions of Azulfidine and Motrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Markedly reduced food intake
Multi-organ failure (multisystem organ failure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Abdominal pain
Hepatocellular damage (liver damage)
Renal failure (kidney dysfunction)
Activated partial thromboplastin time prolonged
Blood bilirubin increased
Skin infection

40-49:

Blindness
Blood pressure decreased
Crying
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fear, focus
Feeling hot
Gallbladder operation
Respiratory tract infection
Rigors (an episode of shaking or exaggerated shivering)
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
Influenza
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pneumonia
Tuberculosis (a bacterial infection by mycobacterium tuberculosis)
White blood cell count increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Haematocrit decreased
Haemoglobin decreased

60+:

Skin ulcer
Abdominal discomfort
Clavicle fracture
Diarrhoea
Drug ineffective
Dry eye (lack of adequate tears)
Fall
Finger deformity (a deformed position of the finger)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Granulocyte count increased

What are the existing conditions these people have? *

Overdose: 3 people, 10.71%
Osteoporosis (bones weak and more likely to break): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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