Azulfidine and Naprosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azulfidine (sulfasalazine) and Naprosyn (naproxen). Common drug interactions include drug hypersensitivity among females and infection susceptibility increased among males.

The phase IV clinical study analyzes what interactions people have when they take Azulfidine and Naprosyn. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Azulfidine?

Azulfidine has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis. eHealthMe is studying from 7,997 Azulfidine users. Check the latest studies of Azulfidine.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

On Jul, 11, 2026

45 people who take Azulfidine and Naprosyn together, and have interactions are studied.

Azulfidine and Naprosyn drug interactions.

What are the common drug interactions of Azulfidine and Naprosyn, by gender? *:

female:

Drug hypersensitivity
Haematemesis (vomiting of blood)
Melaena (the passage of black, tarry stools)
Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematocrit decreased
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Abdominal pain

male:

Infection susceptibility increased
Nasopharyngitis (inflammation of the nasopharynx)
Chest discomfort
Disease progression
Drug hypersensitivity
Dry mouth
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Headache (pain in head)

What are the common drug interactions of Azulfidine and Naprosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Chest pain
Dyspnoea (difficult or laboured respiration)

20-29:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Abdominal pain
Anxiety
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Depression
Diarrhoea
Gallbladder non-functioning
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

n/a

40-49:

Infection susceptibility increased
Nasopharyngitis (inflammation of the nasopharynx)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Asthenia (weakness)
Chest discomfort
Disease progression
Dry mouth
Dysgeusia (disorder of the sense of taste)

50-59:

Haematemesis (vomiting of blood)
Melaena (the passage of black, tarry stools)
Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematocrit decreased
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Acute myocardial infarction (acute heart attack)
Anaemia (lack of blood)

60+:

Drug hypersensitivity
Activities of daily living impaired
Asthenia (weakness)
Drug effect decreased
Hypoaesthesia (reduced sense of touch or sensation)
Joint swelling
Micturition urgency (urgency to pass the urine)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 11 people, 24.44%
Psoriasis (immune-mediated disease that affects the skin): 8 people, 17.78%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 8.89%
Urinary Tract Infection: 3 people, 6.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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