B12 and Slo-niacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take B12 (cobalamin) and Slo-niacin (niacin and niacinamide (vitamin b3)). Common drug interactions include drug ineffective among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take B12 and Slo-niacin. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,894 B12 users. Check the latest studies of B12.

What is Slo-niacin?

Slo-niacin has active ingredients of niacin and niacinamide (vitamin b3). It is often used in high blood cholesterol. eHealthMe is studying from 258 Slo-niacin users. Check the latest studies of Slo-niacin.

On Jul, 06, 2026

25 people who take B12 and Slo-niacin together, and have interactions are studied.

What are the common drug interactions of B12 and Slo-Niacin, by gender? *:

female:

Drug ineffective
Sinus arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle)
Back pain
Breast cancer
Dry eye (lack of adequate tears)
Eye pain
Fungal skin infection
Migraine (headache)
Mobility decreased (ability to move is reduced)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Diarrhoea
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Blindness
Blood testosterone decreased
Chills (felling of cold)
Coagulopathy (blood's ability to clot is impaired)
Constipation
Dizziness postural

What are the common drug interactions of B12 and Slo-Niacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain lower
Back pain
Chills (felling of cold)
Erythema (redness of the skin)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)

50-59:

n/a

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Diarrhoea
Back pain
Blindness
Blood testosterone decreased
Breast cancer
Dizziness postural
Dry eye (lack of adequate tears)
Dyspnoea exertional (breathlessness or shortness of breath)
Essential hypertension (primary hypertension)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 32.00%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 2 people, 8.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.00%
Insomnia (sleeplessness): 2 people, 8.00%
High Blood Pressure: 2 people, 8.00%
Cough: 2 people, 8.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.00%
Carcinoid Syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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