Macrobid and Multi-organ failure - a phase IV clinical study of FDA data

Summary:

Multi-organ failure is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, also take Prilosec, and have Crohn's disease.

The phase IV clinical study analyzes which people have Multi-organ failure when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Multi-organ failure?

Multi-organ failure (multisystem organ failure) is found to be associated with 1,395 drugs and 2,278 conditions by eHealthMe. Check the latest studies of Multi-organ failure.

On Jul, 06, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 11 people (0.13%) have Multi-organ failure.

Could Macrobid cause Multi-organ failure?

Among these 11 people:

What is the gender of people who have Multi-organ failure when taking Macrobid? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Multi-organ failure when taking Macrobid? *

What are other drugs people take besides Macrobid? *

What are other side effects people have besides Multi-organ failure? *

Acute Kidney Failure: 7 people, 63.64%
Fever: 4 people, 36.36%
Hypotension (abnormally low blood pressure): 4 people, 36.36%
Fatigue (feeling of tiredness): 3 people, 27.27%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 3 people, 27.27%
Nausea (feeling of having an urge to vomit): 3 people, 27.27%
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 3 people, 27.27%
Thrombocytopenia (decrease of platelets in blood): 3 people, 27.27%
Pneumonia: 3 people, 27.27%
Hepatic Failure (liver failure): 2 people, 18.18%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 18.18%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 18.18%
Renal Impairment (severely reduced kidney function): 1 person, 9.09%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 9.09%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 9.09%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 9.09%
Pain: 1 person, 9.09%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 9.09%
Immunodeficiency Disorders: 1 person, 9.09%
Chest Pain: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Multi-organ failure?

- Check whether Multi-organ failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Multi-organ failure treatments and more:

Multi-organ failure (32,834 reports)

How severe was Multi-organ failure and when was it recovered:

Multi-organ failure in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Multi-organ failure and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multi-organ failure:

Multi-organ failure (1,395 drugs)

Browse all the conditions that are associated with Multi-organ failure:

Multi-organ failure (2,278 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.