Santyl and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Santyl (collagenase) and Methotrexate (methotrexate sodium). Common drug interactions include chronic kidney disease among females and ascites among males.

The phase IV clinical study analyzes what interactions people have when they take Santyl and Methotrexate. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Santyl?

Santyl has active ingredients of collagenase. eHealthMe is studying from 1,479 Santyl users. Check the latest studies of Santyl.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 06, 2026

17 people who take Santyl and Methotrexate together, and have interactions are studied.

Santyl and Methotrexate drug interactions.

What are the common drug interactions of Santyl and Methotrexate, by gender? *:

female:

Chronic kidney disease
Acute myocardial infarction (acute heart attack)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Osteoporosis (bones weak and more likely to break)
Overdose
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Hypotension (abnormally low blood pressure)
Infection

male:

Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Hepatic failure (liver failure)
Hypotension (abnormally low blood pressure)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Klebsiella infection
Livedo reticularis (a lace-like purplish discoloration of the skin)
Pancreatitis (inflammation of pancreas)
Pleural effusion (water on the lungs)
Rectal haemorrhage (bleeding from anus)

What are the common drug interactions of Santyl and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

50-59:

Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasal oedema (fluid collection in nose)
Oedema peripheral (superficial swelling)
Peripheral swelling
Renal disorder (kidney disease)
Rhinalgia (pain in the nose)
Surgery
Swelling

60+:

Acute myocardial infarction (acute heart attack)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Osteoporosis (bones weak and more likely to break)
Overdose
Chronic kidney disease
Drug ineffective
Herpes zoster
Renal failure (kidney dysfunction)
Rheumatic heart disease (permanent damage to the heart following rheumatic fever)

What are the existing conditions these people have? *

Pain: 5 people, 29.41%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 17.65%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 17.65%
High Blood Pressure: 2 people, 11.76%
Gastric Ulcer (stomach ulcer): 2 people, 11.76%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 11.76%
Indigestion: 2 people, 11.76%
Depression: 2 people, 11.76%
Constipation: 2 people, 11.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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