Baclofen and Combipatch drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Baclofen (baclofen) and Combipatch (estradiol; norethindrone acetate). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Baclofen and Combipatch. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Baclofen?

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. eHealthMe is studying from 108,662 Baclofen users. Check the latest studies of Baclofen.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.



On Jul, 21, 2026

20 people who take Baclofen and Combipatch together, and have interactions are studied.

Baclofen and Combipatch drug interactions.

What are the common drug interactions of Baclofen and Combipatch, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Cough
  3. Colonoscopy
  4. Dizziness
  5. Dyspnoea (difficult or laboured respiration)
  6. Erythema (redness of the skin)
  7. Headache (pain in head)
  8. Hot flush (sudden feelings of heat)
  9. Injury
  10. Intervertebral disc displacement

male:

n/a

What are the common drug interactions of Baclofen and Combipatch, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Chest pain
  3. Cough
  4. Injection site pain

30-39:

n/a

40-49:

  1. Abdominal pain
  2. Arthropathy
  3. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  4. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  5. Diarrhoea
  6. Fatigue (feeling of tiredness)
  7. Fracture nonunion (permanent failure of healing following a broken bone)
  8. Insomnia (sleeplessness)
  9. Iron deficiency
  10. Oral disorder (mouth disease)

50-59:

  1. Dizziness
  2. Dyspnoea (difficult or laboured respiration)
  3. Erythema (redness of the skin)
  4. Headache (pain in head)
  5. Hot flush (sudden feelings of heat)
  6. Injury
  7. Insomnia (sleeplessness)
  8. Intervertebral disc displacement
  9. Neck pain
  10. Pharyngitis (inflammation of the pharynx, causing a sore throat)

60+:

  1. Drug hypersensitivity
  2. Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 30.00%
  2. Pain: 4 people, 20.00%
  3. Urinary Tract Infection: 3 people, 15.00%
  4. Premature Menopause: 3 people, 15.00%
  5. Neuropathy Peripheral (surface nerve damage): 3 people, 15.00%
  6. Nausea (feeling of having an urge to vomit): 3 people, 15.00%
  7. Type 2 Diabetes: 2 people, 10.00%
  8. Hypertriglyceridaemia (excess of triglycerides in the blood): 2 people, 10.00%
  9. Lipodystrophy Acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired): 2 people, 10.00%
  10. Pneumonia: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Baclofen and Combipatch?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Baclofen and Combipatch:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Baclofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Combipatch:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Baclofen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Combipatch and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on baclofen and estradiol; norethindrone acetate (the active ingredients of Baclofen and Combipatch, respectively), and Baclofen and Combipatch (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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