Baclofen and Urecholine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Baclofen (baclofen) and Urecholine (bethanechol chloride). Common drug interactions include sinus headache among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Baclofen and Urecholine. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Baclofen?

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. eHealthMe is studying from 108,664 Baclofen users. Check the latest studies of Baclofen.

What is Urecholine?

Urecholine has active ingredients of bethanechol chloride. eHealthMe is studying from 555 Urecholine users. Check the latest studies of Urecholine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

55 people who take Baclofen and Urecholine together, and have interactions are studied.

Baclofen and Urecholine drug interactions.

What are the common drug interactions of Baclofen and Urecholine, by gender? *:

female:

Sinus headache (headache caused by sinus infections)
Dysarthria (speech disorder)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Alopecia (absence of hair from areas of the body)
Aphasia (damage to the parts of the brain that control language)
Back disorder
Catheter related complication
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Haemoglobin decreased
Hypersomnia (excessive daytime sleepiness (eds))

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Coma (state of unconsciousness lasting more than six hours)
Oedema peripheral (superficial swelling)
Overdose
Respiratory rate decreased (less breathing rate/min)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Unresponsive to stimuli
Vasoplegia syndrome (low systemic vascular resistance)
Fall
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)

What are the common drug interactions of Baclofen and Urecholine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Upper respiratory tract infection

10-19:

n/a

20-29:

Abdominal distension
Feeding tube complication
Wound infection staphylococcal
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Implant site erosion
Skin disorder (skin disease)
Device related infection

30-39:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Hepatic enzyme increased
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Oedema peripheral (superficial swelling)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Aseptic necrosis bone
Dyskinesia (abnormality or impairment of voluntary movement)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Haematocrit decreased

40-49:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Influenza like illness
Papillary thyroid cancer
Dysarthria (speech disorder)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Disease recurrence
Weight decreased
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Application site pain
Ataxia (loss of full control of bodily movements)

50-59:

Scratch
Sedation
Septic shock (shock due to blood infection)
Suicide attempt
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Vision blurred
Visual field defect
Visual impairment
Wound necrosis (damaged cell of wound)
Fall

60+:

Catheter site erythema (redness of skin at catheter site)
Implant site pain
Hypotension (abnormally low blood pressure)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Muscle rigidity (muscle stiffness)
Muscular weakness (muscle weakness)
Oedema peripheral (superficial swelling)
Overdose
Respiratory rate decreased (less breathing rate/min)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 28 people, 50.91%
Gait Disturbance: 9 people, 16.36%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 7 people, 12.73%
Constipation: 5 people, 9.09%
Pain: 4 people, 7.27%
Migraine (headache): 4 people, 7.27%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 7.27%
Asthma: 4 people, 7.27%
Neuropathy Peripheral (surface nerve damage): 3 people, 5.45%
Nausea (feeling of having an urge to vomit): 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

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