Azasan and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Azasan (azathioprine) and Methotrexate (methotrexate sodium). Common drug interactions include cardiac flutter among females and drug eruption among males.

The phase IV clinical study analyzes what interactions people have when they take Azasan and Methotrexate. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Azasan?

Azasan has active ingredients of azathioprine. eHealthMe is studying from 413 Azasan users. Check the latest studies of Azasan.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12 people who take Azasan and Methotrexate together, and have interactions are studied.

Azasan and Methotrexate drug interactions.

What are the common drug interactions of Azasan and Methotrexate, by gender? *:

female:

Cardiac flutter (abnormal heart rhythm)
Diarrhoea
Heart rate increased
Infusion site rash
Erythema (redness of the skin)
Infusion site warmth
Dyslipidaemia (abnormal amount of lipids)
Feeling hot
Infusion site erythema (reddening of the skin at infusion site)
Muscle tightness

male:

Drug eruption (adverse drug reaction of the skin)
Drug ineffective
Epistaxis (bleed from the nose)
Hypersensitivity
Muscle spasms (muscle contraction)
Pain in extremity
Pneumonia
Stomatitis (inflammation of mucous membrane of mouth)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the common drug interactions of Azasan and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiac flutter (abnormal heart rhythm)
Diarrhoea
Headache (pain in head)
Heart rate increased
Infusion site rash
Erythema (redness of the skin)
Infusion site warmth
Feeling hot
Infusion site erythema (reddening of the skin at infusion site)
Muscle tightness

40-49:

n/a

50-59:

Oral pain
Arthropathy
Drug ineffective
Dry mouth
Fatigue (feeling of tiredness)
Headache (pain in head)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)

60+:

Dyslipidaemia (abnormal amount of lipids)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Breast cancer

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 5 people, 41.67%
Uveitis (inflammation of the uvea): 1 person, 8.33%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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