Bactrim and Lodine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Lodine (etodolac). Common drug interactions include hyperplasia among females and acute myeloid leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Lodine. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Lodine?

Lodine has active ingredients of etodolac. It is often used in pain. eHealthMe is studying from 3,846 Lodine users. Check the latest studies of Lodine.

On Jul, 13, 2026

81 people who take Bactrim and Lodine together, and have interactions are studied.

What are the common drug interactions of Bactrim and Lodine, by gender? *:

female:

Hyperplasia (enlargement of an organ or tissue)
Impaired healing
Oral discomfort (pain or irritation in mouth)
Papilloma (small, noncancerous (benign) tumour)
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Procedural pain
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tooth fracture
Tooth loss
Weight decreased

male:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Death
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Atrioventricular block second degree (heart block second degree)
Back injury
Blood glucose increased
Bradycardia (abnormally slow heart action)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Cardiac arrest

What are the common drug interactions of Bactrim and Lodine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Appendicitis (inflammation of the appendix)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Chronic hepatitis (long lasting inflammation of liver)
Gastritis (inflammation of stomach)
Pancreatic enzymes increased
Vomiting
Abdominal pain

20-29:

Abdominal pain upper
Aspartate aminotransferase increased
Autoimmune hepatitis
Blood alkaline phosphatase increased
Chest pain
Dizziness
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Flushing (the warm, red condition of human skin)

30-39:

Depression
Anxiety
Arthralgia (joint pain)
Emotional distress
Fracture
Fractured sacrum
Gait disturbance
Hip fracture
Joint dislocation (a joint position is changed from normal position)
Joint injury

40-49:

Dyskinesia (abnormality or impairment of voluntary movement)
Alopecia (absence of hair from areas of the body)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Blood glucose decreased
Blood glucose increased
Blood urea nitrogen/creatinine ratio increased

50-59:

Depression
Fall
Insomnia (sleeplessness)
Joint effusion (presence of extra fluid in joint covering)
Muscle spasms (muscle contraction)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoporosis (bones weak and more likely to break)
Panic reaction
Psychogenic pain disorder
Social avoidant behaviour (avoiding social connection a personality disorder)

60+:

Rash
Urticaria (rash of round, red welts on the skin that itch intensely)
Bone pain
Deformity (disfigurement)
Dental caries
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dysgeusia (disorder of the sense of taste)
Emotional distress
Face oedema (swelling of face)
Gingival swelling (gums swelling)

What are the existing conditions these people have? *

Stress And Anxiety: 32 people, 39.51%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 18.52%
Metastases To Bone (cancer spreads to bone): 14 people, 17.28%
Breast Cancer: 14 people, 17.28%
Bone Pain: 13 people, 16.05%
Breast Cancer Metastatic: 7 people, 8.64%

* Approximation only. Some reports may have incomplete information.

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